The SLC25 Carrier Family: Important Transport Proteins in Mitochondrial Physiology and Pathology.
bioenergetics
impaired transport mechanism
mitochondrial disease
mitochondrial physiology
pathological mutations
Journal
Physiology (Bethesda, Md.)
ISSN: 1548-9221
Titre abrégé: Physiology (Bethesda)
Pays: United States
ID NLM: 101208185
Informations de publication
Date de publication:
01 09 2020
01 09 2020
Historique:
entrez:
14
8
2020
pubmed:
14
8
2020
medline:
8
7
2021
Statut:
ppublish
Résumé
Members of the mitochondrial carrier family (SLC25) transport a variety of compounds across the inner membrane of mitochondria. These transport steps provide building blocks for the cell and link the pathways of the mitochondrial matrix and cytosol. An increasing number of diseases and pathologies has been associated with their dysfunction. In this review, the molecular basis of these diseases is explained based on our current understanding of their transport mechanism.
Identifiants
pubmed: 32783608
doi: 10.1152/physiol.00009.2020
pmc: PMC7611780
mid: EMS135878
doi:
Substances chimiques
Mitochondrial Proteins
0
Organic Anion Transporters
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
302-327Subventions
Organisme : Medical Research Council
ID : MC_UU_00015/1
Pays : United Kingdom
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