Head Movements Control the Activity of Primary Visual Cortex in a Luminance-Dependent Manner.
head movements
luminance
somatostatin-expressing inhibitory neurons
vestibular system
visual cortex
Journal
Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320
Informations de publication
Date de publication:
11 11 2020
11 11 2020
Historique:
received:
31
01
2020
revised:
20
05
2020
accepted:
02
07
2020
pubmed:
14
8
2020
medline:
29
12
2020
entrez:
14
8
2020
Statut:
ppublish
Résumé
The vestibular system broadcasts head-movement-related signals to sensory areas throughout the brain, including visual cortex. These signals are crucial for the brain's ability to assess whether motion of the visual scene results from the animal's head movements. However, how head movements affect visual cortical circuits remains poorly understood. Here, we discover that ambient luminance profoundly transforms how mouse primary visual cortex (V1) processes head movements. While in darkness, head movements result in overall suppression of neuronal activity; in ambient light, the same head movements trigger excitation across all cortical layers. This light-dependent switch in how V1 processes head movements is controlled by somatostatin-expressing (SOM) inhibitory neurons, which are excited by head movements in dark, but not in light. This study thus reveals a light-dependent switch in the response of V1 to head movements and identifies a circuit in which SOM cells are key integrators of vestibular and luminance signals.
Identifiants
pubmed: 32783882
pii: S0896-6273(20)30521-3
doi: 10.1016/j.neuron.2020.07.004
pmc: PMC7666077
mid: NIHMS1612045
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
500-511.e5Subventions
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY025668
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests The authors declare no competing interests.
Références
J Neurosci. 2007 Sep 5;27(36):9742-56
pubmed: 17804635
Brain. 1996 Feb;119 ( Pt 1):101-10
pubmed: 8624674
Nature. 2017 Nov 8;551(7679):232-236
pubmed: 29120427
Exp Brain Res. 1982;45(3):451-5
pubmed: 7067779
Neuron. 2017 Jan 18;93(2):299-307
pubmed: 28103478
Sci Rep. 2016 Oct 21;6:35689
pubmed: 27767085
J Comp Neurol. 2007 May 20;502(3):339-57
pubmed: 17366604
Cereb Cortex. 2016 Jun;26(6):2612-25
pubmed: 25979090
J Neurosci. 2006 May 10;26(19):5069-82
pubmed: 16687498
J Neurosci. 2010 Dec 15;30(50):16796-808
pubmed: 21159951
Annu Rev Neurosci. 2008;31:125-50
pubmed: 18338968
J Neurophysiol. 1998 Oct;80(4):1816-27
pubmed: 9772241
Nat Neurosci. 2013 Aug;16(8):1068-76
pubmed: 23817549
Neuron. 2017 Jul 19;95(2):399-411.e8
pubmed: 28728025
J Neurophysiol. 2004 Jul;92(1):20-35
pubmed: 15212435
Neuron. 2019 Feb 6;101(3):500-513.e5
pubmed: 30635232
Eur J Neurosci. 2002 Oct;16(8):1569-86
pubmed: 12405971
Nature. 2016 Oct 20;538(7625):383-387
pubmed: 27732573
J Neurophysiol. 2001 Nov;86(5):2559-70
pubmed: 11698542
J Neurophysiol. 2001 Feb;85(2):886-99
pubmed: 11160520
Neuron. 2002 Dec 5;36(5):869-79
pubmed: 12467590
Neuron. 2020 Nov 11;108(3):512-525.e4
pubmed: 32783881
Neuron. 2017 Sep 13;95(6):1420-1432.e5
pubmed: 28910624
Neuron. 2018 Apr 4;98(1):179-191.e6
pubmed: 29551490
J Neurophysiol. 1979 Nov;42(6):1495-1517
pubmed: 115968
J Neurosci. 2018 Feb 14;38(7):1622-1633
pubmed: 29326172
Elife. 2019 Mar 18;8:
pubmed: 30883329
PLoS One. 2009 Jul 07;4(7):e6099
pubmed: 19584920
J Neurosci. 2008 Jul 23;28(30):7520-36
pubmed: 18650330
Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1210-5
pubmed: 24398523
J Neurosci. 2006 Jan 4;26(1):73-85
pubmed: 16399674
Neuron. 2018 Dec 5;100(5):1241-1251.e7
pubmed: 30521779
Elife. 2019 May 23;8:
pubmed: 31115334
J Neurosci. 2015 Apr 15;35(15):5926-34
pubmed: 25878265
J Neurophysiol. 2001 Apr;85(4):1436-43
pubmed: 11287467
J Neurosci. 2006 Dec 27;26(52):13537-47
pubmed: 17192437
Neuron. 2012 Feb 23;73(4):814-28
pubmed: 22365553
Neuron. 2014 Apr 16;82(2):474-85
pubmed: 24656931