Immunometabolism and autoimmunity.
Journal
Current opinion in immunology
ISSN: 1879-0372
Titre abrégé: Curr Opin Immunol
Pays: England
ID NLM: 8900118
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
08
06
2020
revised:
11
07
2020
accepted:
15
07
2020
pubmed:
14
8
2020
medline:
5
10
2021
entrez:
14
8
2020
Statut:
ppublish
Résumé
Over the last few years, immune cell metabolism has become one of the most stimulating areas of investigation in the field of immunology. Compelling evidence has revealed that metabolic pathways are closely associated to cell functions and immune cells adopt defined metabolic programs to sustain their activity and respond to micro-environmental demands. It is now clear that alterations in cell metabolism can favour dysregulation typical of autoreactive immune cells, thus sustaining loss of immunological self-tolerance. In this short review, we highlight the main metabolic alterations associated with both innate and adaptive immune cells in autoimmune conditions, such as multiple sclerosis (MS) and type 1 diabetes (T1D). We also summarize recent findings reporting the use of pharmacological agents, which modulate the immunometabolism to possibly control immune responses during autoimmune disorders.
Identifiants
pubmed: 32784085
pii: S0952-7915(20)30071-6
doi: 10.1016/j.coi.2020.07.002
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
10-17Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.