Modeling oncogenic herpesvirus infections in humanized mice.

Animals Animals, Genetically Modified Disease Models, Animal Gammaherpesvirinae / pathogenicity Hematopoietic Stem Cell Transplantation / methods Hematopoietic Stem Cells / immunology Herpesviridae Infections / virology Humans Mice Mice, Inbred NOD

Journal

Current opinion in virology
ISSN: 1879-6265
Titre abrégé: Curr Opin Virol
Pays: Netherlands
ID NLM: 101560941

Informations de publication

Date de publication:
10 2020
Historique:
received: 15 06 2020
accepted: 04 07 2020
pubmed: 14 8 2020
medline: 26 8 2021
entrez: 14 8 2020
Statut: ppublish

Résumé

The creation of humanized mice generally involves the reconstitution of immunodeficient mice with human immune constituents. Different methodologies have been employed, and significant progress has been made towards the development of robustly humanized mouse models. Some of the techniques used include the injection of mature human immune cells, the injection of human hematopoietic stem cells (HSCs) capable of reconstituting radiation-depleted murine bone marrow, and the implantation of human fetal liver and thymus fragments under the kidney capsule to create a thymic organoid that can support thympoiesis. This review will serve as a brief introduction to the three most commonly utilized humanized mouse models for the study of gammaherpesvirus-driven pathogenesis, and highlight some of the critical discoveries these models have enabled.

Identifiants

DOI: 10.1016/j.coviro.2020.07.005 PMID: 32784124 PMC: PMC7755680
pubmed: 32784124
pii: S1879-6257(20)30048-1
doi: 10.1016/j.coviro.2020.07.005
pmc: PMC7755680
mid: NIHMS1612485
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

90-96

Subventions

Organisme : NCI NIH HHS
ID : P01 CA019014
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA163217
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009156
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE028211
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA239583
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA228172
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE018281
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA096500
Pays : United States

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

Auteurs

Philip T Lange (PT)

Department of Microbiology and Immunology and Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.

Blossom Damania (B)

Department of Microbiology and Immunology and Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States. Electronic address: blossom_damania@med.unc.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Modeling oncogenic herpesvirus infections in...
questionsmedicales.fr › Stades d'organismes › Organismes génétiquement modifiés › Animal génétiquement modifié › Modeling oncogenic herpesvirus infections in...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Modeling oncogenic herpesvirus infections in...
questionsmedicales.fr › Virus › Virus oncogènes › Virus tumoraux à ADN › Gammaherpesvirinae › Modeling oncogenic herpesvirus infections in...
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation cellulaire › Transplantation de cellules souches › Transplantation de cellules souches hématopoïétiques › Modeling oncogenic herpesvirus infections in...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système hématopoïétique › Cellules de la moelle osseuse › Cellules souches hématopoïétiques › Modeling oncogenic herpesvirus infections in...
questionsmedicales.fr › Infection › Maladies virales › Infections à virus à ADN › Infections à Herpesviridae › Modeling oncogenic herpesvirus infections in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Modeling oncogenic herpesvirus infections in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Modeling oncogenic herpesvirus infections in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée NOD › Modeling oncogenic herpesvirus infections in...