Notch Transduction in Non-Small Cell Lung Cancer.
Notch signaling
lung cancer
lung cancer therapy
lung development
non-small cell lung cancer
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
08 Aug 2020
08 Aug 2020
Historique:
received:
24
06
2020
revised:
01
08
2020
accepted:
05
08
2020
entrez:
14
8
2020
pubmed:
14
8
2020
medline:
20
2
2021
Statut:
epublish
Résumé
The evolutionarily-conserved Notch signaling pathway plays critical roles in cell communication, function and homeostasis equilibrium. The pathway serves as a cell-to-cell juxtaposed molecular transducer and is crucial in a number of cell processes including cell fate specification, asymmetric cell division and lateral inhibition. Notch also plays critical roles in organismal development, homeostasis, and regeneration, including somitogenesis, left-right asymmetry, neurogenesis, tissue repair, self-renewal and stemness, and its dysregulation has causative roles in a number of congenital and acquired pathologies, including cancer. In the lung, Notch activity is necessary for cell fate specification and expansion, and its aberrant activity is markedly linked to various defects in club cell formation, alveologenesis, and non-small cell lung cancer (NSCLC) development. In this review, we focus on the role this intercellular signaling device plays during lung development and on its functional relevance in proximo-distal cell fate specification, branching morphogenesis, and alveolar cell determination and maturation, then revise its involvement in NSCLC formation, progression and treatment refractoriness, particularly in the context of various mutational statuses associated with NSCLC, and, lastly, conclude by providing a succinct outlook of the therapeutic perspectives of Notch targeting in NSCLC therapy, including an overview on prospective synthetic lethality approaches.
Identifiants
pubmed: 32784481
pii: ijms21165691
doi: 10.3390/ijms21165691
pmc: PMC7461113
pii:
doi:
Substances chimiques
Receptors, Notch
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : American Cancer Society
ID : 11-053-01-IRG (ACS-KCI), 14-238-04-IRG (ACS-KCI)
Organisme : Karmanos Cancer Institute / McLaren
ID : Infrastructure and Initiative Awards
Organisme : Wayne State University
ID : Grants Boost Awards 2014 & 2019
Références
Biochem Biophys Res Commun. 2014 Feb 21;444(4):670-5
pubmed: 24502949
Stem Cells. 2018 Mar;36(3):377-391
pubmed: 29148109
Mech Dev. 2000 Nov;98(1-2):95-8
pubmed: 11044610
Curr Opin Struct Biol. 2007 Oct;17(5):530-5
pubmed: 17964136
Genes Dev. 2014 Sep 1;28(17):1929-39
pubmed: 25184679
Int Rev Cell Mol Biol. 2016;323:107-27
pubmed: 26944620
Annu Rev Physiol. 1984;46:617-28
pubmed: 6370120
Cell. 2015 Oct 8;163(2):394-405
pubmed: 26435104
Nat Rev Genet. 2017 Oct;18(10):613-623
pubmed: 28649135
Cancer Cell. 2012 Aug 14;22(2):222-34
pubmed: 22897852
Cancer Discov. 2018 Jul;8(7):822-835
pubmed: 29773717
Transl Respir Med. 2013 Dec;1(1):6
pubmed: 27234388
J Biol Chem. 2008 Oct 24;283(43):29532-44
pubmed: 18694942
Front Oncol. 2018 Jul 24;8:267
pubmed: 30087852
Cancer Manag Res. 2019 Jan 21;11:943-953
pubmed: 30718965
Stem Cell Res Ther. 2018 Nov 23;9(1):327
pubmed: 30470250
Pharmacol Ther. 2013 Aug;139(2):95-110
pubmed: 23458608
Cancer Res. 2009 Apr 1;69(7):3060-8
pubmed: 19318552
Zhonghua Yu Fang Yi Xue Za Zhi. 2018 Mar 6;52(3):243-252
pubmed: 29973002
Cell Rep. 2015 Jan 13;10(2):239-52
pubmed: 25558064
Mol Cancer Ther. 2017 Dec;16(12):2759-2769
pubmed: 28978720
Clin Cancer Res. 2015 Jun 15;21(12):2695-703
pubmed: 25724527
Protein Cell. 2011 Feb;2(2):99-107
pubmed: 21380642
Proc Natl Acad Sci U S A. 1937 Mar;23(3):133-7
pubmed: 16588136
Dev Growth Differ. 2020 Jan;62(1):67-79
pubmed: 31613406
Eur J Cancer. 2018 Nov;103:88-97
pubmed: 30218977
BMC Res Notes. 2018 Apr 16;11(1):247
pubmed: 29661224
Mol Oncol. 2014 Mar;8(2):207-20
pubmed: 24309677
Cancer Cell. 2016 Mar 14;29(3):367-378
pubmed: 26977885
Elife. 2019 Oct 21;8:
pubmed: 31631837
Br J Cancer. 2013 Aug 20;109(4):943-9
pubmed: 23868004
Cell Tissue Res. 2017 Mar;367(3):427-444
pubmed: 28144783
Medicine (Baltimore). 2016 May;95(20):e3715
pubmed: 27196489
Nature. 2007 Aug 16;448(7155):807-10
pubmed: 17676035
Cell Rep. 2019 Mar 12;26(11):2942-2954.e5
pubmed: 30865885
Cancer Cell. 2011 Jun 14;19(6):754-64
pubmed: 21665149
Cancer Res. 2005 May 1;65(9):3555-61
pubmed: 15867348
Dev Biol. 2010 Nov 15;347(2):301-14
pubmed: 20816795
J Cell Physiol. 2018 Dec;233(12):9548-9562
pubmed: 29953591
Cancer Res. 2011 Sep 15;71(18):6010-8
pubmed: 21803744
Sci Signal. 2018 Jun 05;11(533):
pubmed: 29871910
J Immunol. 2010 Oct 15;185(8):4609-17
pubmed: 20844195
J Clin Oncol. 2017 May 10;35(14):1561-1569
pubmed: 28350521
J Cancer Res Ther. 2019;15(7):1547-1552
pubmed: 31939436
Cell. 1991 Aug 23;66(4):649-61
pubmed: 1831692
Nat Commun. 2014;5:3261
pubmed: 24531128
Cancer Res. 2010 Dec 1;70(23):9937-48
pubmed: 21118965
Clin Cancer Res. 2013 Apr 15;19(8):1972-80
pubmed: 23444212
Oncol Lett. 2018 Mar;15(3):3415-3421
pubmed: 29467866
Neoplasia. 2011 Jan;13(1):1-11
pubmed: 21245935
Front Oncol. 2019 Oct 18;9:1088
pubmed: 31681616
Med Oncol. 2013;30(2):595
pubmed: 23645556
Mol Cell Biol. 1986 Sep;6(9):3094-108
pubmed: 3097517
Korean J Intern Med. 2017 May;32(3):514-522
pubmed: 28407465
Ann Oncol. 2018 Sep 1;29(9):1911-1917
pubmed: 30060061
Cancer. 2010 Dec 15;116(24):5676-85
pubmed: 20737536
Cancer Res. 2008 May 15;68(10):3562-5
pubmed: 18483235
R I Med J (2013). 2015 Oct 01;98(10):25-8
pubmed: 26422542
Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):8242-7
pubmed: 27364009
Dev Cell. 2007 Aug;13(2):283-97
pubmed: 17681138
Cancer Res. 2013 Oct 1;73(19):5974-84
pubmed: 23943799
Oncol Rep. 2018 Jul;40(1):155-164
pubmed: 29781034
Oncogene. 2010 Apr 29;29(17):2488-98
pubmed: 20154720
Development. 2009 May;136(10):1751-9
pubmed: 19369400
Cancer Cell. 2016 Oct 10;30(4):519-532
pubmed: 27728803
Development. 2011 Aug;138(16):3569-78
pubmed: 21771811
J Thorac Cardiovasc Surg. 2009 Mar;137(3):580-6
pubmed: 19258070
Biol Open. 2012 Jul 15;1(7):677-91
pubmed: 23213461
Dev Cell. 2017 May 8;41(3):228-241
pubmed: 28486129
Am J Physiol Lung Cell Mol Physiol. 2010 Jan;298(1):L45-56
pubmed: 19897741
Nature. 2015 Dec 3;528(7580):127-31
pubmed: 26580007
Nature. 2014 Mar 13;507(7491):190-4
pubmed: 24499815
J R Soc Interface. 2016 May;13(118):
pubmed: 27170649
J Cell Biochem. 2015 Jun;116(6):1019-27
pubmed: 25561332
Clin Cancer Res. 2015 Jan 1;21(1):60-7
pubmed: 25231399
Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22293-8
pubmed: 20007775
Nature. 2019 Nov;575(7781):217-223
pubmed: 31666701
Development. 2009 Jul;136(13):2297-307
pubmed: 19502490
J Cancer. 2017 May 11;8(7):1292-1300
pubmed: 28607605
Cell. 2008 Jan 25;132(2):247-58
pubmed: 18243100
Nat Rev Cancer. 2014 Aug;14(8):535-46
pubmed: 25056707
J Natl Cancer Inst. 2000 Aug 16;92(16):1355-7
pubmed: 10944559
Cell. 2009 Apr 17;137(2):216-33
pubmed: 19379690
BMC Cancer. 2015 Apr 25;15:311
pubmed: 25907971
Development. 2000 Sep;127(18):3913-21
pubmed: 10952889
Dev Cell. 2006 Nov;11(5):655-69
pubmed: 17084358
Development. 2016 Jan 1;143(1):54-65
pubmed: 26586225
Sci Signal. 2019 Feb 05;12(567):
pubmed: 30723171
Oncogene. 2003 Apr 3;22(13):1988-97
pubmed: 12673204
Oncogene. 2018 Jul;37(28):3839-3851
pubmed: 29643474
Anticancer Res. 2014 Jun;34(6):2991-6
pubmed: 24922664
Oncol Lett. 2017 Jan;13(1):506-510
pubmed: 28123589
EMBO J. 2003 Nov 3;22(21):5769-79
pubmed: 14592975
Clin Cancer Res. 2014 Aug 1;20(15):4154-66
pubmed: 24907115
Anat Rec (Hoboken). 2007 Aug;290(8):958-73
pubmed: 17654674
Cancer Prev Res (Phila). 2017 Sep;10(9):514-524
pubmed: 28754664
Cell Cycle. 2011 Aug 15;10(16):2806-15
pubmed: 21822053
Genetics. 2006 Jan;172(1):389-99
pubmed: 16157679
J Carcinog. 2013 Mar 16;12:6
pubmed: 23599688
Clin Cancer Res. 2012 Feb 15;18(4):945-55
pubmed: 22190591
Nat Commun. 2015 Apr 13;6:6727
pubmed: 25865356
Brain Res Bull. 2016 Sep;126(Pt 2):199-206
pubmed: 27133790
Cancer Discov. 2012 May;2(5):401-4
pubmed: 22588877
Cancer Cell. 2003 Jun;3(6):525-30
pubmed: 12842081
Clin Cancer Res. 2019 Dec 1;25(23):6958-6966
pubmed: 31506387
Adv Exp Med Biol. 2018;1066:99-122
pubmed: 30030824
Cancer Discov. 2020 Jan;10(1):54-71
pubmed: 31658955
J Cancer Res Clin Oncol. 2016 May;142(5):981-93
pubmed: 26838758
Mol Cell Biol. 2009 Sep;29(17):4640-52
pubmed: 19564409
Curr Biol. 2002 Nov 19;12(22):1923-7
pubmed: 12445385
Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):4910-5
pubmed: 22411819
Target Oncol. 2018 Feb;13(1):89-98
pubmed: 29188408
Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):4952-7
pubmed: 24586047
Development. 2006 May;133(9):1611-24
pubmed: 16613830
Eur J Cancer. 2016 Mar;56:1-9
pubmed: 26798966
Int J Mol Med. 2020 Feb;45(2):279-297
pubmed: 31894255
Nature. 2017 May 18;545(7654):360-364
pubmed: 28489825
Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):255-60
pubmed: 24367082
Eur J Cancer. 2013 Nov;49(16):3559-72
pubmed: 23916913
Development. 2015 Jul 15;142(14):2452-63
pubmed: 26062937
BMC Dev Biol. 2009 Dec 01;9:60
pubmed: 19948068
Development. 1998 Sep;125(18):3615-23
pubmed: 9716527
Semin Cell Dev Biol. 2010 Aug;21(6):638-45
pubmed: 20226260
Sci Adv. 2019 Jul 24;5(7):eaaw6455
pubmed: 31355336
Trends Cell Biol. 2015 Nov;25(11):697-707
pubmed: 26437585
Nature. 2014 May 15;509(7500):371-5
pubmed: 24739965
J Thorac Oncol. 2015 Oct;10(10):e106-9
pubmed: 26398830
Science. 2017 Mar 24;355(6331):1320-1324
pubmed: 28254785
Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17531-6
pubmed: 23047698
Nat Med. 2016 Mar;22(3):270-7
pubmed: 26855149
Development. 2012 Dec 1;139(23):4365-73
pubmed: 23132245
Front Oncol. 2018 Nov 07;8:460
pubmed: 30464927
Nat Commun. 2018 Aug 10;9(1):3198
pubmed: 30097569
Cell. 1985 Dec;43(3 Pt 2):567-81
pubmed: 3935325
Mayo Clin Proc. 2008 May;83(5):584-94
pubmed: 18452692
Nature. 2015 Aug 6;524(7563):47-53
pubmed: 26168399
Pharmacol Ther. 2014 Feb;141(2):140-9
pubmed: 24076266
Nature. 2007 Aug 2;448(7153):561-6
pubmed: 17625570
Onco Targets Ther. 2017 Apr 24;10:2267-2279
pubmed: 28479857
Cancer Res. 2014 Oct 1;74(19):5572-84
pubmed: 25125655
Clin Lung Cancer. 2014 Jan;15(1):58-66
pubmed: 24210543
Genes Cancer. 2014 May;5(5-6):212-25
pubmed: 25061504
Proc Natl Acad Sci U S A. 2004 Oct 5;101(40):14449-54
pubmed: 15452354
Cell. 1996 Jun 14;85(6):863-73
pubmed: 8681381
Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2407-2412
pubmed: 29463737
Anticancer Res. 2018 Nov;38(11):6299-6308
pubmed: 30396950
Mol Biol Cell. 2005 Feb;16(2):927-42
pubmed: 15574878
Haematologica. 2020 Apr 23;:
pubmed: 32327503
Cancer Res. 2009 Oct 1;69(19):7672-80
pubmed: 19773430
J Hematol Oncol. 2013 Jan 05;6:3
pubmed: 23289374
PLoS One. 2014 Jan 28;9(1):e86459
pubmed: 24489728
Sci Signal. 2013 Apr 02;6(269):pl1
pubmed: 23550210
J Cell Sci. 2010 Jan 15;123(Pt 2):213-24
pubmed: 20048339
Genes Dev. 2001 Dec 15;15(24):3243-8
pubmed: 11751630
Cancer Res. 2011 Mar 15;71(6):2212-21
pubmed: 21406400
Development. 2014 Feb;141(3):502-13
pubmed: 24449833
J Environ Pathol Toxicol Oncol. 2019;38(1):61-68
pubmed: 30806291
Cell Rep. 2015 Dec 29;13(12):2679-86
pubmed: 26711336
Int J Oncol. 2014 Oct;45(4):1430-6
pubmed: 25096400
Mol Cancer. 2018 Feb 19;17(1):33
pubmed: 29455666
PLoS One. 2009 Dec 14;4(12):e8248
pubmed: 20011520
Curr Biol. 2006 Nov 21;16(22):2228-33
pubmed: 17088062
J Exp Med. 2019 Mar 4;216(3):674-687
pubmed: 30737256
J Clin Invest. 2013 Jul;123(7):3025-36
pubmed: 23921127
Invest New Drugs. 2013 Oct;31(5):1182-91
pubmed: 23860641
Oncogene. 2015 Jan 29;34(5):578-88
pubmed: 24509876
Cancer Res. 2001 Apr 1;61(7):3200-5
pubmed: 11306509
Development. 2011 Aug;138(16):3533-43
pubmed: 21791528
Dev Biol. 2003 Apr 1;256(1):61-72
pubmed: 12654292
Sci Rep. 2015 May 21;5:10338
pubmed: 25996086
Dev Cell. 2006 Nov;11(5):641-53
pubmed: 17084357
Cancer Res. 2007 Sep 1;67(17):8051-7
pubmed: 17804716
J R Soc Interface. 2017 Nov;14(136):
pubmed: 29187638
Cancer Cell. 2013 Jul 8;24(1):59-74
pubmed: 23845442
Curr Opin Genet Dev. 2009 Aug;19(4):323-8
pubmed: 19447603
Dev Biol. 2011 Jun 15;354(2):242-52
pubmed: 21513708
Lancet Oncol. 2017 Jan;18(1):42-51
pubmed: 27932068
Elife. 2019 May 29;8:
pubmed: 31140976
Front Immunol. 2018 Jun 01;9:1230
pubmed: 29910816
Dev Dyn. 2013 Jun;242(6):678-86
pubmed: 23526493