Antitumoral Drug: Loaded Hybrid Nanocapsules Based on Chitosan with Potential Effects in Breast Cancer Therapy.
Antineoplastic Agents
/ pharmacology
Breast Neoplasms
/ drug therapy
Cell Survival
/ drug effects
Chitosan
/ chemistry
Drug Liberation
Female
Fluorouracil
/ pharmacology
Humans
Kinetics
MCF-7 Cells
Magnetite Nanoparticles
/ chemistry
Nanocapsules
/ chemistry
Particle Size
Spectroscopy, Fourier Transform Infrared
Static Electricity
Temperature
Thermogravimetry
5-fluorouracil
antitumoral therapy
breast carcinoma
hybrid nanocapsules
smart polymers
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
07 Aug 2020
07 Aug 2020
Historique:
received:
24
06
2020
revised:
30
07
2020
accepted:
31
07
2020
entrez:
14
8
2020
pubmed:
14
8
2020
medline:
20
2
2021
Statut:
epublish
Résumé
Cancer remains one of the world's most devastating diseases and is responsible for more than 20% of all deaths. It is defined as uncontrolled proliferation of cells and spreads rapidly to healthy tissue. Controlled drug delivery systems offers great opportunities for the development of new non-invasive strategies for the treatment of cancers. The main advantage of these systems is their capacity to accumulate in tumors via enhanced permeability and retention effects. In the present study, an innovative hybrid drug delivery system based on nanocapsules obtained from the interfacial condensation between chitosan and poly(N-vinyl pyrrolidone-
Identifiants
pubmed: 32784525
pii: ijms21165659
doi: 10.3390/ijms21165659
pmc: PMC7460861
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Magnetite Nanoparticles
0
Nanocapsules
0
Chitosan
9012-76-4
Fluorouracil
U3P01618RT
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
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