Electroresponsive Silk-Based Biohybrid Composites for Electrochemically Controlled Growth Factor Delivery.
biohybrid
conductivity
growth factor
nerve repair
reduced graphene oxide
silk
stimuli-responsive delivery
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
07 Aug 2020
07 Aug 2020
Historique:
received:
06
07
2020
revised:
28
07
2020
accepted:
01
08
2020
entrez:
14
8
2020
pubmed:
14
8
2020
medline:
14
8
2020
Statut:
epublish
Résumé
Stimuli-responsive materials are very attractive candidates for on-demand drug delivery applications. Precise control over therapeutic agents in a local area is particularly enticing to regulate the biological repair process and promote tissue regeneration. Macromolecular therapeutics are difficult to embed for delivery, and achieving controlled release over long-term periods, which is required for tissue repair and regeneration, is challenging. Biohybrid composites incorporating natural biopolymers and electroconductive/active moieties are emerging as functional materials to be used as coatings, implants or scaffolds in regenerative medicine. Here, we report the development of electroresponsive biohybrid composites based on
Identifiants
pubmed: 32784563
pii: pharmaceutics12080742
doi: 10.3390/pharmaceutics12080742
pmc: PMC7463593
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Engineering and Physical Sciences Research Council
ID : EP/N509565/1, 1786315
Organisme : Engineering and Physical Sciences Research Council
ID : EP/R512564/1, 2065445
Organisme : Engineering and Physical Sciences Research Council
ID : EP/R003823/1
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/L0137971/1
Pays : United Kingdom
Organisme : Agency for Science, Technology and Research
ID : A*STAR Research Attachment Programme
Organisme : Royal Society Research Grant
ID : RG160449
Références
Adv Mater. 2018 Apr;30(15):e1706442
pubmed: 29504165
Adv Healthc Mater. 2020 Aug;9(16):e2000174
pubmed: 32583574
Adv Mater. 2016 Apr 13;28(14):2692-8
pubmed: 26840865
PLoS One. 2017 Jun 1;12(6):e0178355
pubmed: 28570647
J Transl Med. 2012 Nov 29;10:239
pubmed: 23190582
Nanoscale Res Lett. 2013 Mar 22;8(1):132
pubmed: 23522102
J Biomed Mater Res A. 2014 Jun;102(6):2039-54
pubmed: 23852673
Drug Discov Today. 2015 Oct;20(10):1271-83
pubmed: 26360055
Adv Healthc Mater. 2014 Aug;3(8):1334-43
pubmed: 24799416
Nanoscale. 2020 Jan 2;12(2):610-622
pubmed: 31829371
Biomed Mater. 2018 May 04;13(4):044107
pubmed: 29537390
J Toxicol Environ Health A. 2003 Oct 24;66(20):1909-26
pubmed: 14514433
Sci Rep. 2013 Oct 03;3:2481
pubmed: 24089083
ACS Nano. 2018 Nov 27;12(11):10582-10620
pubmed: 30387986
Materials (Basel). 2018 Jul 01;11(7):
pubmed: 29966387
Adv Sci (Weinh). 2019 Feb 27;6(9):1800808
pubmed: 31065509
J R Soc Interface. 2009 Sep 6;6(38):801-10
pubmed: 19068472
Mol Inform. 2017 Aug;36(8):
pubmed: 28436609
ACS Nano. 2014 Feb 25;8(2):1834-43
pubmed: 24428340
Biomacromolecules. 2018 Dec 10;19(12):4542-4553
pubmed: 30387602
Biomater Sci. 2018 May 29;6(6):1299-1311
pubmed: 29725688
Regul Toxicol Pharmacol. 2019 Feb;101:35-47
pubmed: 30439387
Sensors (Basel). 2017 Jun 09;17(6):
pubmed: 28598393
Nanoscale. 2018 Jul 5;10(25):11820-11830
pubmed: 29920573
Int J Biol Macromol. 2001 Aug 20;29(2):91-7
pubmed: 11518580
Sci Rep. 2017 Jan 12;7:40572
pubmed: 28079192
Biomed Res Int. 2016;2016:3856262
pubmed: 27556032
Adv Healthc Mater. 2018 Dec;7(23):e1800308
pubmed: 30260575
Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):14444-51
pubmed: 26598696
Nat Commun. 2011 Sep 20;2:476
pubmed: 21934660
Biomaterials. 2016 Nov;106:193-204
pubmed: 27566868
Nanotechnology. 2011 Feb 4;22(5):055705
pubmed: 21178230
Adv Drug Deliv Rev. 2018 Apr;129:148-168
pubmed: 29262296
Sensors (Basel). 2020 Mar 28;20(7):
pubmed: 32231114
Mater Sci Eng C Mater Biol Appl. 2019 Sep;102:405-414
pubmed: 31147011
Bone Res. 2018 Aug 29;6:25
pubmed: 30181921
Acta Biomater. 2014 Jun;10(6):2341-53
pubmed: 24556448
Biomacromolecules. 2014 Feb 10;15(2):635-43
pubmed: 24417502
Part Fibre Toxicol. 2016 Oct 31;13(1):57
pubmed: 27799056
Materials (Basel). 2019 Jan 16;12(2):
pubmed: 30654487
Nanomaterials (Basel). 2019 Apr 09;9(4):
pubmed: 30970633
Nat Chem. 2014 Jul;6(7):596-602
pubmed: 24950329
Injury. 2012 May;43(5):553-72
pubmed: 21269624
J Control Release. 2020 Apr 10;320:337-346
pubmed: 31931048
Curr Med Chem. 2004 Sep;11(18):2383-97
pubmed: 15379704