Development and Evaluation of Novel and Highly Sensitive Single-Tube Nested Real-Time RT-PCR Assays for SARS-CoV-2 Detection.


Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
07 Aug 2020
Historique:
received: 30 06 2020
revised: 28 07 2020
accepted: 05 08 2020
entrez: 14 8 2020
pubmed: 14 8 2020
medline: 21 8 2020
Statut: epublish

Résumé

Sensitive molecular assays are critical for coronavirus disease 2019 (COVID-19) diagnosis. Here, we designed and evaluated two single-tube nested (STN) real-time RT-PCR assays, targeting SARS-CoV-2 RdRp/Hel and

Identifiants

pubmed: 32784770
pii: ijms21165674
doi: 10.3390/ijms21165674
pmc: PMC7461039
pii:
doi:

Substances chimiques

Coronavirus Nucleocapsid Proteins 0
Nucleocapsid Proteins 0
Phosphoproteins 0
Viral Nonstructural Proteins 0
nucleocapsid phosphoprotein, SARS-CoV-2 0
Coronavirus RNA-Dependent RNA Polymerase EC 2.7.7.48
NSP12 protein, SARS-CoV-2 EC 2.7.7.48
RNA-Dependent RNA Polymerase EC 2.7.7.48

Types de publication

Evaluation Study Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : the donations of Richard Yu and Carol Yu, the Shaw Foundation Hong Kong, May Tam Mak Mei Yin, Michael Seak-Kan Tong, Respiratory Viral Research Foundation Limited, Hui Ming, Hui Hoy and Chow Sin Lan Charity Fund Limited, Chan Yin Chuen Memorial Charitable
ID : NA
Organisme : the Consultancy Service for Enhancing Laboratory Surveillance of Emerging Infectious Diseases and Research Capability on Antimicrobial Resistance for Department of Health of the Hong Kong Special Administrative Region Government
ID : NA
Organisme : the Theme-Based Research Scheme of the Research Grants Council, Hong Kong Special Administrative Region
ID : T11/707/15

Références

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Auteurs

Cyril Chik-Yan Yip (CC)

Department of Microbiology, Queen Mary Hospital, Hong Kong, China.

Siddharth Sridhar (S)

Department of Microbiology, The University of Hong Kong, Hong Kong, China.
State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China.
Carol Yu Centre for Infection, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

Kit-Hang Leung (KH)

Department of Microbiology, The University of Hong Kong, Hong Kong, China.

Anthony Chin-Ki Ng (AC)

Department of Microbiology, The University of Hong Kong, Hong Kong, China.

Kwok-Hung Chan (KH)

Department of Microbiology, The University of Hong Kong, Hong Kong, China.
State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China.
Carol Yu Centre for Infection, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

Jasper Fuk-Woo Chan (JF)

Department of Microbiology, The University of Hong Kong, Hong Kong, China.
State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China.
Carol Yu Centre for Infection, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

Owen Tak-Yin Tsang (OT)

Department of Medicine and Geriatrics, Princess Margaret Hospital, Hong Kong, China.

Ivan Fan-Ngai Hung (IF)

Department of Medicine, The University of Hong Kong, Hong Kong, China.

Vincent Chi-Chung Cheng (VC)

Department of Microbiology, Queen Mary Hospital, Hong Kong, China.

Kwok-Yung Yuen (KY)

Department of Microbiology, Queen Mary Hospital, Hong Kong, China.
Department of Microbiology, The University of Hong Kong, Hong Kong, China.
State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China.
Carol Yu Centre for Infection, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

Kelvin Kai-Wang To (KK)

Department of Microbiology, The University of Hong Kong, Hong Kong, China.
State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China.
Carol Yu Centre for Infection, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

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