The Role of the Liver-Specific microRNA, miRNA-122 in the HCV Replication Cycle.
RNA stabilization 6
hepatitis C virus 1
miR-122 3
microRNA 2
pathogenesis 8
replication 4
translation 5
tropism 7
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
07 Aug 2020
07 Aug 2020
Historique:
received:
10
07
2020
revised:
04
08
2020
accepted:
05
08
2020
entrez:
14
8
2020
pubmed:
14
8
2020
medline:
20
2
2021
Statut:
epublish
Résumé
Hepatitis C virus (HCV) replication requires annealing of a liver specific microRNA, miR-122 to 2 sites on 5' untranslated region (UTR). While, microRNAs downregulate gene expression by binding to the 3' untranslated region of the target mRNA, in this case, the microRNA anneals to the 5'UTR of the viral genomes and upregulates the viral lifecycle. In this review, we explore the current understandings of the mechanisms by which miR-122 promotes the HCV lifecycle, and its contributions to pathogenesis. Annealing of miR-122 has been reported to (a) stimulate virus translation by promoting the formation of translationally active internal ribosome entry site (IRES) RNA structure, (b) stabilize the genome, and (c) induce viral genomic RNA replication. MiR-122 modulates lipid metabolism and suppresses tumor formation, and sequestration by HCV may influence virus pathogenesis. We also discuss the possible use of miR-122 as a biomarker for chronic hepatitis and as a therapeutic target. Finally, we discuss roles for miR-122 and other microRNAs in promoting other viruses.
Identifiants
pubmed: 32784807
pii: ijms21165677
doi: 10.3390/ijms21165677
pmc: PMC7460827
pii:
doi:
Substances chimiques
MicroRNAs
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Natural Sciences and Engineering Research Council of Canada
ID : RGPIN-2018-06335
Organisme : CIHR
ID : MOP-133458
Pays : Canada
Organisme : University of Saskatchewan
ID : CoMBRIDGE
Références
Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7263-8
pubmed: 20360559
Nucleic Acids Res. 2018 Jun 1;46(10):5139-5158
pubmed: 29672716
Sci Rep. 2016 Aug 03;6:30939
pubmed: 27484655
N Engl J Med. 2013 May 2;368(18):1685-94
pubmed: 23534542
Curr Gene Ther. 2015;15(2):142-50
pubmed: 25537773
Ann Transl Med. 2019 Oct;7(20):577
pubmed: 31807558
J Virol. 2015 May;89(9):4857-65
pubmed: 25673723
Nucleic Acids Res. 2020 Aug 18;:
pubmed: 32810257
J Clin Invest. 2012 Aug;122(8):2884-97
pubmed: 22820290
Nucleic Acids Res. 2019 Jun 4;47(10):5307-5324
pubmed: 30941417
Nucleic Acids Res. 2017 Dec 1;45(21):12441-12454
pubmed: 29040738
PLoS One. 2016 May 03;11(5):e0152090
pubmed: 27138141
Nat Commun. 2018 Jul 4;9(1):2613
pubmed: 29973597
J Virol. 2015 Jun;89(12):6294-311
pubmed: 25855736
J Hepatol. 2011 Sep;55(3):602-611
pubmed: 21241755
Nucleic Acids Res. 2011 Sep 1;39(17):7716-29
pubmed: 21653556
Ann Oncol. 2014 Jul;25(7):1404-1410
pubmed: 24799461
RNA. 2007 Oct;13(10):1675-92
pubmed: 17684232
PLoS Pathog. 2007 Jul;3(7):e103
pubmed: 17658949
J Clin Invest. 2012 Aug;122(8):2871-83
pubmed: 22820288
Int J Mol Sci. 2016 Sep 01;17(9):
pubmed: 27598137
PLoS Pathog. 2017 Oct 30;13(10):e1006694
pubmed: 29084265
Mol Cell. 2016 Oct 20;64(2):320-333
pubmed: 27720646
Biochem Soc Trans. 2008 Dec;36(Pt 6):1220-3
pubmed: 19021529
Nucleic Acids Res. 2013 Apr;41(7):4230-40
pubmed: 23416544
Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4991-6
pubmed: 21383155
Nucleic Acids Res. 2008 Mar;36(4):1153-62
pubmed: 18158304
J Virol. 2014 Jul;88(13):7199-209
pubmed: 24719423
J Virol. 2007 Aug;81(16):8374-83
pubmed: 17537845
CA Cancer J Clin. 2017 Sep;67(5):411-431
pubmed: 28683174
RNA. 2009 Aug;15(8):1528-42
pubmed: 19541769
J Virol. 2005 Aug;79(16):10126-37
pubmed: 16051805
Mol Cell Biol. 2004 Sep;24(18):7878-90
pubmed: 15340051
J Virol. 2011 Aug;85(16):7954-64
pubmed: 21632751
Virology. 2011 Feb 20;410(2):336-44
pubmed: 21185047
Science. 2005 Sep 2;309(5740):1577-81
pubmed: 16141076
J Gen Virol. 2016 Jun;97(6):1381-1394
pubmed: 26935756
Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):2192-7
pubmed: 25646476
Ann Hepatol. 2019 Mar - Apr;18(2):304-309
pubmed: 31053544
Cell Host Microbe. 2008 Jul 17;4(1):77-85
pubmed: 18621012
mSphere. 2015 Nov 25;1(1):
pubmed: 27303683
Nucleic Acids Res. 2018 Oct 12;46(18):9776-9792
pubmed: 30053137
J Hepatol. 2006 Oct;45(4):529-38
pubmed: 16879891
J Gastroenterol. 2014 Apr;49(4):589-93
pubmed: 24531873
Nat Struct Biol. 2003 Dec;10(12):1033-8
pubmed: 14578934
Biosci Rep. 2019 Sep 6;39(9):
pubmed: 31427483
Front Immunol. 2019 Nov 05;10:2525
pubmed: 31787967
J Virol. 2018 Jul 17;92(15):
pubmed: 29769341
Gastroenterology. 1994 May;106(5):1291-300
pubmed: 7513667
J Clin Invest. 2011 Apr;121(4):1386-96
pubmed: 21364282
BMJ Open Gastroenterol. 2017 Dec 20;4(1):e000181
pubmed: 29333275
Front Endocrinol (Lausanne). 2018 Aug 03;9:402
pubmed: 30123182
RNA Biol. 2004 Jul;1(2):106-13
pubmed: 17179747
Cell Host Microbe. 2014 Aug 13;16(2):257-264
pubmed: 25121753
J Hepatol. 2010 Sep;53(3):583-5
pubmed: 20579761
PLoS Pathog. 2019 May 10;15(5):e1007467
pubmed: 31075158
Nucleic Acids Res. 2004 Aug 16;32(14):4368-76
pubmed: 15314207
Hepatology. 2008 Jan;47(1):321-31
pubmed: 18161707
Nat Cell Biol. 2007 Sep;9(9):1089-97
pubmed: 17721513
Ann Hepatol. 2019 Nov - Dec;18(6):869-878
pubmed: 31477445
J Virol. 2012 Apr;86(7):3723-35
pubmed: 22278227
PLoS One. 2013 Jun 24;8(6):e67437
pubmed: 23826300
J Virol. 2004 Dec;78(23):13153-62
pubmed: 15542667
Cell Host Microbe. 2016 Mar 9;19(3):409-23
pubmed: 26962949
Nucleic Acids Res. 2020 Jun 4;48(10):5555-5571
pubmed: 32374844
Cell. 2015 Mar 12;160(6):1099-110
pubmed: 25768906
Antimicrob Agents Chemother. 2015 Jan;59(1):599-608
pubmed: 25385103
Hepatology. 2018 Aug;68(2):435-448
pubmed: 28859226
Nat Commun. 2017 Jan 09;8:13882
pubmed: 28067225
Lancet. 2017 Feb 18;389(10070):674-675
pubmed: 28087068
Virology. 1999 Feb 15;254(2):288-96
pubmed: 9986795
Swiss Med Wkly. 2018 Jan 29;148:w14560
pubmed: 29376557
mBio. 2014 Oct 14;5(5):e01933-14
pubmed: 25316698
J Virol. 2009 Nov;83(22):11989-95
pubmed: 19740989
AIDS Res Hum Retroviruses. 2016 Jul;32(7):660-7
pubmed: 26974581
Nucleic Acids Res. 1999 Mar 15;27(6):1457-63
pubmed: 10037806
Nat Commun. 2014 Nov 18;5:5408
pubmed: 25403145
Cancer Res. 2007 Jul 1;67(13):6092-9
pubmed: 17616664
Philos Trans R Soc Lond B Biol Sci. 2017 Mar 19;372(1716):
pubmed: 28138065
J Gen Virol. 2019 Feb;100(2):217-226
pubmed: 30652963
Wiley Interdiscip Rev RNA. 2013 Nov-Dec;4(6):665-76
pubmed: 23881584
J Hepatol. 2006 Oct;45(4):607-16
pubmed: 16901579
J Virol. 2013 Jul;87(13):7338-47
pubmed: 23616647
J Virol. 1995 Oct;69(10):6367-75
pubmed: 7666538
Nat Commun. 2018 Dec 14;9(1):5321
pubmed: 30552326
J Virol. 2010 Jul;84(13):6615-25
pubmed: 20427538
J Hepatol. 2015 Feb;62(2):448-57
pubmed: 25308172
J Virol. 2012 Jul;86(13):7372-83
pubmed: 22532678
Nat Rev Microbiol. 2007 Jan;5(1):29-38
pubmed: 17128284
Cell Metab. 2006 Feb;3(2):87-98
pubmed: 16459310
Oncogene. 2009 Oct 8;28(40):3526-36
pubmed: 19617899
RNA Biol. 2013 Jun;10(6):919-23
pubmed: 23770926
Dig Dis. 2020;38(1):46-52
pubmed: 31422405
Cell Host Microbe. 2015 Feb 11;17(2):217-28
pubmed: 25662750
J Virol. 2017 Jun 9;91(13):
pubmed: 28404852
J Biol Chem. 2009 Nov 13;284(46):32015-27
pubmed: 19726678
EMBO J. 2008 Dec 17;27(24):3300-10
pubmed: 19020517
Virology. 2013 Feb 5;436(1):179-90
pubmed: 23245472
Cell Mol Life Sci. 2017 Feb;74(4):747-760
pubmed: 27677491
PLoS Pathog. 2017 May 11;13(5):e1006374
pubmed: 28494029
Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):8197-8202
pubmed: 30038017
Science. 2001 Mar 9;291(5510):1959-62
pubmed: 11239155
Nucleic Acids Res. 2014 Jan;42(2):1257-69
pubmed: 24141094
Oncogene. 2016 Jun 9;35(23):2979-90
pubmed: 26434584
PLoS One. 2013;8(2):e56272
pubmed: 23405269
Front Immunol. 2018 Jun 28;9:1480
pubmed: 30002657
Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3193-8
pubmed: 21220300
Comput Struct Biotechnol J. 2020 Mar 05;18:548-557
pubmed: 32211130