Naturally-Occurring Alkaloids of Plant Origin as Potential Antimicrobials against Antibiotic-Resistant Infections.
alkaloids
antibiotic resistance
antimicrobials
methicillin-resistant Staphylococcus aureus
natural products
plant-derived alkaloids
structure–activity relationship
vancomycin-resistant enterococci
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
09 Aug 2020
09 Aug 2020
Historique:
received:
10
07
2020
revised:
29
07
2020
accepted:
08
08
2020
entrez:
14
8
2020
pubmed:
14
8
2020
medline:
5
3
2021
Statut:
epublish
Résumé
Antibiotic resistance is now considered a worldwide problem that puts public health at risk. The onset of bacterial strains resistant to conventional antibiotics and the scarcity of new drugs have prompted scientific research to re-evaluate natural products as molecules with high biological and chemical potential. A class of natural compounds of significant importance is represented by alkaloids derived from higher plants. In this review, we have collected data obtained from various research groups on the antimicrobial activities of these alkaloids against conventional antibiotic-resistant strains. In addition, the structure-function relationship was described and commented on, highlighting the high potential of alkaloids as antimicrobials.
Identifiants
pubmed: 32784887
pii: molecules25163619
doi: 10.3390/molecules25163619
pmc: PMC7466045
pii:
doi:
Substances chimiques
Alkaloids
0
Anti-Bacterial Agents
0
Biological Products
0
Plant Extracts
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Piano Operativo Nazionale (PON)
ID : ARS01_00432 PROGEMA
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca
ID : PRIN 2017-"Targeting Hedgehog pathway: Virtual screening identification and sustainable synthesis of novel Smo and Gli inhibitors and their pharmacological drug delivery strategies for improved therapeutic effects in tumors
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca
ID : Dipartimenti di Eccellenza- L. 232/2016 and Sapienza University of Rome (Project RM11816436113D8A
Références
Planta Med. 1979 Jul;36(3):204-7
pubmed: 482432
Lipids. 2005 Nov;40(11):1081-105
pubmed: 16459921
J Pharm Pharm Sci. 2008;11(4):90-4
pubmed: 19183517
Expert Opin Investig Drugs. 2019 Jul;28(7):629-642
pubmed: 31232099
Bioorg Med Chem Lett. 2012 Nov 15;22(22):6962-6
pubmed: 23058886
Phytother Res. 2014 Feb;28(2):305-7
pubmed: 24497124
Science. 2020 May 1;368(6490):
pubmed: 32355003
Toxins (Basel). 2019 Sep 01;11(9):
pubmed: 31480508
J Pept Sci. 2018 Feb;24(2):
pubmed: 29349894
Biomacromolecules. 2019 May 13;20(5):1876-1888
pubmed: 31013061
3 Biotech. 2017 Jul;7(3):172
pubmed: 28660459
PLoS One. 2015 Nov 25;10(11):e0143863
pubmed: 26606133
J Chromatogr. 1965 Sep;19(3):531-9
pubmed: 5864081
Appl Biochem Biotechnol. 2010 Apr;160(8):2467-74
pubmed: 19578993
Eur J Med Chem. 2018 Aug 5;156:554-562
pubmed: 30025349
ACS Med Chem Lett. 2019 Feb 26;10(4):639-643
pubmed: 30996810
Antimicrob Agents Chemother. 2003 Feb;47(2):704-8
pubmed: 12543681
J Nat Prod. 2020 Mar 27;83(3):770-803
pubmed: 32162523
Scand J Infect Dis. 2010 Jul;42(6-7):500-5
pubmed: 20380543
Metabolites. 2019 Nov 01;9(11):
pubmed: 31683833
Fitoterapia. 2012 Sep;83(6):1110-4
pubmed: 22579839
Curr Pharm Des. 2016;22(12):1808-50
pubmed: 26719050
Microbiol Res. 2017 Mar;196:44-68
pubmed: 28164790
Biochim Biophys Acta. 2008 Sep;1780(9):1054-61
pubmed: 18549823
Antimicrob Resist Infect Control. 2019 Jul 16;8:118
pubmed: 31346459
Toxins (Basel). 2019 Nov 11;11(11):
pubmed: 31717922
J Infect Dev Ctries. 2014 Feb 13;8(2):129-36
pubmed: 24518621
J Pharmacol Exp Ther. 1986 Feb;236(2):488-93
pubmed: 3080587
J Antibiot (Tokyo). 2016 Oct;69(10):741-746
pubmed: 26932407
Exp Ther Med. 2018 Jan;15(1):467-472
pubmed: 29387199
Molecules. 2020 Jan 19;25(2):
pubmed: 31963860
Chem Biol Drug Des. 2015 Sep;86(3):272-83
pubmed: 25476148
Antibiotics (Basel). 2020 Jun 13;9(6):
pubmed: 32545761
Foodborne Pathog Dis. 2011 Aug;8(8):869-74
pubmed: 21524196
Antimicrob Agents Chemother. 1993 Jan;37(1):128-9
pubmed: 8431010
J Antimicrob Chemother. 2011 Aug;66(8):1766-72
pubmed: 21622974
P T. 2015 May;40(5):344-52
pubmed: 25987823
Front Cell Infect Microbiol. 2020 Mar 17;10:107
pubmed: 32257966
Lett Appl Microbiol. 2019 Sep;69(3):161-167
pubmed: 31267555
Int J Mol Sci. 2017 Nov 20;18(11):
pubmed: 29156609
Molecules. 2017 Jul 20;22(7):
pubmed: 28726740
Curr Pharm Des. 2018;24(6):654-658
pubmed: 29336251
ACS Med Chem Lett. 2020 Jan 30;11(5):760-765
pubmed: 32435382
Front Microbiol. 2012 Apr 23;3:130
pubmed: 22536197
Microbiol Immunol. 2000;44(1):9-15
pubmed: 10711594
Front Microbiol. 2016 Aug 05;7:1223
pubmed: 27547203
Nat Prod Res. 2011 May;25(9):863-75
pubmed: 21491327
Curr Microbiol. 2009 Aug;59(2):181-6
pubmed: 19475447
Protein Pept Lett. 2018;25(12):1155-1162
pubmed: 30381056
Int J Antimicrob Agents. 2014 Nov;44(5):377-86
pubmed: 25130096
J Med Food. 2005 Winter;8(4):454-61
pubmed: 16379555
J Can Dent Assoc. 1990;56(7 Suppl):19-30
pubmed: 2207851
Cell. 2007 Sep 7;130(5):769-74
pubmed: 17803898
Biochemistry. 2005 Dec 20;44(50):16584-93
pubmed: 16342949
J Appl Microbiol. 2015 Apr;118(4):864-72
pubmed: 25604161
Drugs. 2019 May;79(7):705-714
pubmed: 30972660
Curr Opin Pharmacol. 2014 Oct;18:56-60
pubmed: 25254623
Antimicrob Agents Chemother. 2002 Oct;46(10):3133-41
pubmed: 12234835
Fitoterapia. 2020 Jun;143:104558
pubmed: 32198108
Phytomedicine. 2014 Mar 15;21(4):443-7
pubmed: 24262063
Planta Med. 2011 Sep;77(13):1542-4
pubmed: 21341176
Biotechnol Adv. 2015 Dec;33(8):1582-1614
pubmed: 26281720
Nat Prod Commun. 2018 Nov;13(11):
pubmed: 31080542
J Am Chem Soc. 2020 Feb 5;142(5):2187-2192
pubmed: 31951394
Mol Biol (Mosk). 2019 Jul-Aug;53(4):674-684
pubmed: 31397441
Drug Metab Lett. 2014;8(2):119-28
pubmed: 25692301
EXCLI J. 2011 Nov 25;10:252-263
pubmed: 29033706
Curr Biol. 2013 Dec 16;23(24):R1063-5
pubmed: 24501765
Mol Pharmacol. 1988 Feb;33(2):144-7
pubmed: 2893251
Proc Natl Acad Sci U S A. 1991 Jun 1;88(11):4781-5
pubmed: 1675788
Lancet Infect Dis. 2016 Apr;16(4):411-2
pubmed: 27036346
Molecules. 2019 Aug 29;24(17):
pubmed: 31470632
Molecules. 2011 Nov 21;16(11):9651-64
pubmed: 22105714
Phytother Res. 2007 Jul;21(7):653-7
pubmed: 17421058
PLoS One. 2010 Oct 29;5(10):e13745
pubmed: 21060782
Nat Rev Drug Discov. 2015 Feb;14(2):111-29
pubmed: 25614221
EXCLI J. 2018 May 04;17:420-451
pubmed: 29805348
Biochemistry. 2008 Mar 11;47(10):3225-34
pubmed: 18275156
Cancers (Basel). 2019 Oct 09;11(10):
pubmed: 31601026
J Biomol Struct Dyn. 2019 Mar;37(5):1307-1325
pubmed: 29595093
Chem Biol Drug Des. 2013 Apr;81(4):484-90
pubmed: 23290001
Eur J Med Chem. 2018 Sep 5;157:622-656
pubmed: 30125723
Biomed Chromatogr. 2012 Sep;26(9):1096-100
pubmed: 22120837
J Nat Prod. 2019 Jul 26;82(7):1935-1944
pubmed: 31274312
Drug Dev Ind Pharm. 2015 Jun;41(6):989-94
pubmed: 24842547
Int J Pept. 2013;2013:675391
pubmed: 23935642
Phytother Res. 2000 Mar;14(2):139-40
pubmed: 10685116
Int J Antimicrob Agents. 2020 Jul;56(1):106005
pubmed: 32387480
Front Microbiol. 2019 May 15;10:911
pubmed: 31156565
J Toxicol Sci. 2011 Jun;36(3):277-83
pubmed: 21628956
Lancet Infect Dis. 2019 Jan;19(1):56-66
pubmed: 30409683
Int J Med Microbiol. 2013 Aug;303(6-7):324-30
pubmed: 23517691
Int J Med Microbiol. 2013 Aug;303(6-7):318-23
pubmed: 23499479
J Antimicrob Chemother. 2010 Aug;65(8):1694-701
pubmed: 20525733
J Antimicrob Chemother. 2002 Oct;50(4):547-52
pubmed: 12356800
Expert Opin Drug Discov. 2019 May;14(5):417-420
pubmed: 30810395
J Pharmacol Exp Ther. 2002 Aug;302(2):645-50
pubmed: 12130727
P T. 2015 Apr;40(4):277-83
pubmed: 25859123
Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1433-7
pubmed: 10677479
Molecules. 2011 Nov 25;16(12):9819-26
pubmed: 22117171
FEBS J. 2019 Oct;286(19):3874-3891
pubmed: 31144441
J Antimicrob Chemother. 2020 Sep 1;75(9):2564-2572
pubmed: 32514531
Curr Med Chem. 2020;27(9):1405-1419
pubmed: 31333082
Fitoterapia. 2019 Nov;139:104371
pubmed: 31629051
Avicenna J Med Biotechnol. 2017 Jan-Mar;9(1):2-7
pubmed: 28090273
Antimicrob Agents Chemother. 2010 Dec;54(12):5406-12
pubmed: 20855745
Bioorg Med Chem. 2005 Jan 3;13(1):165-74
pubmed: 15582461
J Ethnopharmacol. 2010 Oct 28;132(1):349-54
pubmed: 20691774
BMC Complement Altern Med. 2018 Apr 23;18(1):132
pubmed: 29688864
Future Microbiol. 2012 Aug;7(8):979-90
pubmed: 22913356
Antimicrob Agents Chemother. 2009 Nov;53(11):4673-7
pubmed: 19687245
J Ethnopharmacol. 1999 Aug;66(2):223-6
pubmed: 10433482
Int J Antimicrob Agents. 2005 Nov;26(5):343-56
pubmed: 16323269
J Pharm Pharmacol. 2015 Feb;67(2):264-73
pubmed: 25495516
Evol Med Public Health. 2014 Oct 28;2014(1):147
pubmed: 25355275
J Nat Prod. 2012 Apr 27;75(4):741-6
pubmed: 22482432
J Exp Biol. 1994 Nov;196:251-62
pubmed: 7823026
Chirality. 2016 Mar;28(3):169-80
pubmed: 26729048
Phytochemistry. 2013 Apr;88:74-8
pubmed: 23360667
PLoS One. 2014 May 13;9(5):e97000
pubmed: 24824737
J Biomol Struct Dyn. 2003 Apr;20(5):703-14
pubmed: 12643773
Phytomedicine. 2015 Feb 15;22(2):245-55
pubmed: 25765829
Int J Environ Res Public Health. 2015 Aug 21;12(8):10079-92
pubmed: 26308027
Antimicrob Agents Chemother. 2006 Feb;50(2):810-2
pubmed: 16436753
J Med Microbiol. 2011 Oct;60(Pt 10):1472-1478
pubmed: 21680766