SARS-CoV-2 Entry Inhibitors: Small Molecules and Peptides Targeting Virus or Host Cells.
COVID-19
SARS-CoV-2 entry inhibitors
TMPRSS2
cathepsins
coronavirus
peptides inhibitors
small molecules inhibitors
spike
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
09 Aug 2020
09 Aug 2020
Historique:
received:
15
06
2020
revised:
07
08
2020
accepted:
07
08
2020
entrez:
14
8
2020
pubmed:
14
8
2020
medline:
21
8
2020
Statut:
epublish
Résumé
The pandemic evolution of SARS-CoV-2 infection is forcing the scientific community to unprecedented efforts to explore all possible approaches against COVID-19. In this context, targeting virus entry is a promising antiviral strategy for controlling viral infections. The main strategies pursued to inhibit the viral entry are considering both the virus and the host factors involved in the process. Primarily, direct-acting antivirals rely on inhibition of the interaction between ACE2 and the receptor binding domain (RBD) of the Spike (S) protein or targeting the more conserved heptad repeats (HRs), involved in the membrane fusion process. The inhibition of host TMPRSS2 and cathepsins B/L may represent a complementary strategy to be investigated. In this review, we discuss the development entry inhibitors targeting the S protein, as well as the most promising host targeting strategies involving TMPRSS2 and CatB/L, which have been exploited so far against CoVs and other related viruses.
Identifiants
pubmed: 32784899
pii: ijms21165707
doi: 10.3390/ijms21165707
pmc: PMC7460888
pii:
doi:
Substances chimiques
Angiotensin-Converting Enzyme Inhibitors
0
Antiviral Agents
0
Serine Proteinase Inhibitors
0
Spike Glycoprotein, Coronavirus
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Horizon 2020
ID : 101003551
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