Centromeric Transcription: A Conserved Swiss-Army Knife.
Animals
Centromere
/ genetics
Centromere Protein B
/ metabolism
Chromatin
/ genetics
Chromatin Assembly and Disassembly
Evolution, Molecular
Gene Expression Regulation
Humans
RNA Processing, Post-Transcriptional
RNA, Long Noncoding
RNA, Small Untranslated
Repetitive Sequences, Nucleic Acid
Transcription, Genetic
centromere
chromatin
epigenetics
non-coding RNAs
nucleosomes
transcription
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
09 08 2020
09 08 2020
Historique:
received:
22
07
2020
revised:
05
08
2020
accepted:
07
08
2020
entrez:
14
8
2020
pubmed:
14
8
2020
medline:
24
3
2021
Statut:
epublish
Résumé
In most species, the centromere is comprised of repetitive DNA sequences, which rapidly evolve. Paradoxically, centromeres fulfill an essential function during mitosis, as they are the chromosomal sites wherein, through the kinetochore, the mitotic spindles bind. It is now generally accepted that centromeres are transcribed, and that such transcription is associated with a broad range of functions. More than a decade of work on this topic has shown that centromeric transcripts are found across the eukaryotic tree and associate with heterochromatin formation, chromatin structure, kinetochore structure, centromeric protein loading, and inner centromere signaling. In this review, we discuss the conservation of small and long non-coding centromeric RNAs, their associations with various centromeric functions, and their potential roles in disease.
Identifiants
pubmed: 32784923
pii: genes11080911
doi: 10.3390/genes11080911
pmc: PMC7463856
pii:
doi:
Substances chimiques
Centromere Protein B
0
Chromatin
0
RNA, Long Noncoding
0
RNA, Small Untranslated
0
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Review
Langues
eng
Sous-ensembles de citation
IM
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