Pre-Existing Tumoral B Cell Infiltration and Impaired Genome Maintenance Correlate with Response to Chemoradiotherapy in Locally Advanced Rectal Cancer.
biomarker
gene expression
immune response
neoadjuvant chemoradiotherapy
rectal cancer
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
10 Aug 2020
10 Aug 2020
Historique:
received:
19
05
2020
revised:
20
06
2020
accepted:
01
07
2020
entrez:
14
8
2020
pubmed:
14
8
2020
medline:
14
8
2020
Statut:
epublish
Résumé
Locally advanced rectal cancer (LARC) remains a medical challenge. Reliable biomarkers to predict which patients will significantly respond to neoadjuvant chemoradiotherapy (nCRT) have not been identified. We evaluated baseline genomic and transcriptomic features to detect differences that may help predict response to nCRT. Eligible LARC patients received nCRT (3D-LCRT 50.4 Gy plus capecitabine 825 mg/m2/bid), preceded by three cycles of CAPOX in high systemic-relapse risk tumors, and subsequent surgery. Frozen tumor biopsies at diagnosis were sequenced using a colorectal cancer panel. Transcriptomic data was used for pathway and cell deconvolution inferential algorithms, coupled with immunohistochemical validation. Clinical and molecular data were analyzed according to nCRT outcome. Pathways related to DNA repair and proliferation (
Identifiants
pubmed: 32784964
pii: cancers12082227
doi: 10.3390/cancers12082227
pmc: PMC7464257
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Fondo Argentino Sectorial
ID : FS-PBIT 015/13
Organisme : Fondo para la Investigación Científica y Tecnológica
ID : PPL2011-004
Organisme : Fondation Nelia et Amadeo Barletta
ID : NA
Organisme : Consejo Nacional de Investigaciones Científicas y Técnicas
ID : NA
Organisme : Intergrupo Argentino para el Tratamiento de los Tumores Gastrointestinales
ID : NA
Organisme : Hospital de Gastroenterología Carlos Bonorino Udaondo
ID : NA
Références
Clin Colorectal Cancer. 2019 Jun;18(2):e231-e236
pubmed: 30772135
Cancer Res. 2006 Apr 1;66(7):3370-4
pubmed: 16585155
J Cell Physiol. 2017 Feb;232(2):426-435
pubmed: 27225591
Expert Rev Mol Diagn. 2018 Oct;18(10):887-896
pubmed: 30124091
PLoS One. 2014 Nov 07;9(11):e112189
pubmed: 25380052
Nat Methods. 2019 Jul;16(7):565-566
pubmed: 31217592
J Am Coll Surg. 2016 Apr;222(4):367-74
pubmed: 26897480
Cancer Immunol Res. 2018 Nov;6(11):1388-1400
pubmed: 30266715
Cancers (Basel). 2020 Mar 26;12(4):
pubmed: 32225122
Bioinformatics. 2007 Dec 1;23(23):3251-3
pubmed: 17644558
Genome Biol. 2017 Nov 15;18(1):220
pubmed: 29141660
Dis Colon Rectum. 2015 Jan;58(1):32-44
pubmed: 25489692
Clin Cancer Res. 2018 Aug 1;24(15):3717-3728
pubmed: 29666300
Nat Biotechnol. 2019 Jul;37(7):773-782
pubmed: 31061481
N Engl J Med. 2004 Oct 21;351(17):1731-40
pubmed: 15496622
Dis Colon Rectum. 2016 Dec;59(12):1174-1182
pubmed: 27824703
J Clin Oncol. 1992 Jan;10(1):79-84
pubmed: 1727928
Br J Surg. 2019 Sep;106(10):1381-1392
pubmed: 31197828
Ann Oncol. 2013 Oct;24 Suppl 6:vi81-8
pubmed: 24078665
Clin Cancer Res. 2011 May 1;17(9):3039-47
pubmed: 21224373
Nat Med. 2015 Nov;21(11):1350-6
pubmed: 26457759
Cancer Res. 2017 Nov 1;77(21):e108-e110
pubmed: 29092952
JAMA Oncol. 2018 Jun 14;4(6):e180071
pubmed: 29566109
Genome Res. 2018 Nov;28(11):1747-1756
pubmed: 30341162
Bioinformatics. 2010 Jun 15;26(12):i237-45
pubmed: 20529912
Genome Biol. 2016 Jun 06;17(1):122
pubmed: 27268795
Cancer Biol Ther. 2015;16(8):1160-71
pubmed: 26023803
Genome Res. 2019 Sep;29(9):1555-1565
pubmed: 31439692
PLoS One. 2014 May 06;9(5):e96801
pubmed: 24802416
J Clin Oncol. 2006 Feb 1;24(4):668-74
pubmed: 16446339
Radiat Oncol. 2016 Mar 22;11:50
pubmed: 27005571
Curr Colorectal Cancer Rep. 2015;11(5):275-280
pubmed: 26321890
Br J Cancer. 2017 Nov 7;117(10):1478-1485
pubmed: 28934761
Lancet. 2010 Mar 20;375(9719):1030-47
pubmed: 20304247
CA Cancer J Clin. 2017 May 6;67(3):177-193
pubmed: 28248415
Ann Surg Oncol. 2012 Sep;19(9):2842-52
pubmed: 22526897
Cancer Discov. 2012 May;2(5):401-4
pubmed: 22588877
Int J Radiat Oncol Biol Phys. 2000 Nov 1;48(4):1075-80
pubmed: 11072165
Genome Biol. 2016 Oct 20;17(1):218
pubmed: 27765066
Genet Med. 2019 Apr;21(4):972-981
pubmed: 30287923
Oncoimmunology. 2018 Nov 2;8(1):e1523097
pubmed: 30546963
Clin Cancer Res. 2019 Sep 15;25(18):5561-5571
pubmed: 31253631
J Mol Diagn. 2017 Jan;19(1):4-23
pubmed: 27993330
Genome Med. 2018 Mar 28;10(1):25
pubmed: 29592813
J Clin Oncol. 2005 Dec 1;23(34):8688-96
pubmed: 16246976
Ann Oncol. 2015 Aug;26(8):1722-8
pubmed: 25957330
PLoS One. 2015 Nov 06;10(11):e0142159
pubmed: 26544968
J Natl Cancer Inst. 2014 Sep 22;106(10):
pubmed: 25249540