Toad Venom Antiproliferative Activities on Metastatic Melanoma: Bio-Guided Fractionation and Screening of the Compounds of Two Different Venoms.
bufalin
cardiotonic steroids
high performance liquid chromatography
marinobufagenin
mass spectrometry
melanoma
resistance to drugs
sodium pump
targeted therapies
toad venom
Journal
Biology
ISSN: 2079-7737
Titre abrégé: Biology (Basel)
Pays: Switzerland
ID NLM: 101587988
Informations de publication
Date de publication:
10 Aug 2020
10 Aug 2020
Historique:
received:
23
06
2020
revised:
29
07
2020
accepted:
07
08
2020
entrez:
14
8
2020
pubmed:
14
8
2020
medline:
14
8
2020
Statut:
epublish
Résumé
Melanoma is the most common cancer in young adults, with a constantly increasing incidence. Metastatic melanoma is a very aggressive cancer with a 5-year survival rate of about 22-25%. This is, in most cases, due to a lack of therapies which are effective on the long term. Hence, it is crucial to find new therapeutic agents to increase patient survival. Toad venoms are a rich source of potentially pharmaceutically active compounds and studies have highlighted their possible effect on cancer cells. We focused on the venoms of two different toad species:
Identifiants
pubmed: 32785105
pii: biology9080218
doi: 10.3390/biology9080218
pmc: PMC7464305
pii:
doi:
Types de publication
Journal Article
Langues
eng
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