Hydrogel-Based Localized Nonviral Gene Delivery in Regenerative Medicine Approaches-An Overview.
cardiovascular tissue
controlled delivery
gene therapy
hydrogels
musculoskeletal tissue
nervous tissue
nonviral vectors
wound healing
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
10 Aug 2020
10 Aug 2020
Historique:
received:
22
06
2020
revised:
29
07
2020
accepted:
07
08
2020
entrez:
14
8
2020
pubmed:
14
8
2020
medline:
14
8
2020
Statut:
epublish
Résumé
Hydrogel-based nonviral gene delivery constitutes a powerful strategy in various regenerative medicine scenarios, as those concerning the treatment of musculoskeletal, cardiovascular, or neural tissues disorders as well as wound healing. By a minimally invasive administration, these systems can provide a spatially and temporarily defined supply of specific gene sequences into the target tissue cells that are overexpressing or silencing the original gene, which can promote natural repairing mechanisms to achieve the desired effect. In the present work, we provide an overview of the most avant-garde approaches using various hydrogels systems for controlled delivery of therapeutic nucleic acid molecules in different regenerative medicine approaches.
Identifiants
pubmed: 32785171
pii: pharmaceutics12080752
doi: 10.3390/pharmaceutics12080752
pmc: PMC7464633
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Ministerio de Ciencia, Innovación y Universidades
ID : RTI2018-099389-A-100
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