Pediatric trichodysplasia spinulosa: A report of 2 cases and review of the literature.
pediatric
polyomavirus
transplant
trichodysplasia spinulosa
Journal
Pediatric dermatology
ISSN: 1525-1470
Titre abrégé: Pediatr Dermatol
Pays: United States
ID NLM: 8406799
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
11
05
2020
revised:
15
07
2020
accepted:
21
07
2020
pubmed:
14
8
2020
medline:
15
5
2021
entrez:
14
8
2020
Statut:
ppublish
Résumé
Trichodysplasia spinulosa is a rare disorder caused by the ubiquitous trichodysplasia spinulosa-associated polyomavirus (TSPyV) and characterized clinically by predominately centrofacial, but often generalized, folliculocentric papules with protuberant keratinaceous spines. Although seroprevalence reaches up to 70% in adult populations, TSPyV causes clinical manifestations in a small percentage of patients who are immunosuppressed. Diagnosis can be made using typical clinical and histologic features, SV40T antibody immunostaining, and PCR of various tissues including the keratinaceous spine, skin, serum, urine, and CSF. Various topical and systemic medications have demonstrated variable success. Decreasing or discontinuing immunosuppression has also been shown to improve or alleviate clinical manifestations.
Types de publication
Case Reports
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1023-1029Informations de copyright
© 2020 Wiley Periodicals LLC.
Références
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