Bacterial products in donor airways prevent the induction of lung transplant tolerance.
Journal
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
ISSN: 1600-6143
Titre abrégé: Am J Transplant
Pays: United States
ID NLM: 100968638
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
04
05
2020
revised:
17
07
2020
accepted:
03
08
2020
pubmed:
14
8
2020
medline:
22
6
2021
entrez:
14
8
2020
Statut:
ppublish
Résumé
Although postoperative bacterial infections can trigger rejection of pulmonary allografts, the impact of bacterial colonization of donor grafts on alloimmune responses to transplanted lungs remains unknown. Here, we tested the hypothesis that bacterial products present within donor grafts at the time of implantation promote lung allograft rejection. Administration of the toll-like receptor 2 (TLR2) agonist Pam
Identifiants
pubmed: 32786174
doi: 10.1111/ajt.16256
pmc: PMC7775268
mid: NIHMS1630042
pii: S1600-6135(22)08346-0
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
353-361Subventions
Organisme : NIAID NIH HHS
ID : R01 AI145108
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL151078
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI116501
Pays : United States
Organisme : NHLBI NIH HHS
ID : F32 HL143950
Pays : United States
Organisme : BLRD VA
ID : I01 BX002730
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL094601
Pays : United States
Organisme : VA
ID : 1I01BX002730
Pays : United States
Informations de copyright
© 2020 The American Society of Transplantation and the American Society of Transplant Surgeons.
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