Nanocytometer for smart analysis of peripheral blood and acute myeloid leukemia: a pilot study.

Humans Leukemia, Myeloid, Acute / diagnosis Leukocytes, Mononuclear Monocytes Pilot Projects
PBMCs POC diagnostics acute myeloid leukemia (AML) impedance cytometer machine learning for data treatment nanosensor

Journal

Nano letters
ISSN: 1530-6992
Titre abrégé: Nano Lett
Pays: United States
ID NLM: 101088070

Informations de publication

Date de publication:
09 09 2020
Historique:
pubmed: 14 8 2020
medline: 25 6 2021
entrez: 14 8 2020
Statut: ppublish

Résumé

We realize an ultracompact nanocytometer for real-time impedimetric detection and classification of subpopulations of living cells. Nanoscopic nanowires in a microfluidic channel act as nanocapacitors and measure in real time the change of the amplitude and phase of the output voltage and, thus, the electrical properties of living cells. We perform the cell classification in the human peripheral blood (PBMC) and demonstrate for the first time the possibility to discriminate monocytes and

Identifiants

DOI: 10.1021/acs.nanolett.0c02300 PMID: 32786943
pubmed: 32786943
doi: 10.1021/acs.nanolett.0c02300
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

6572-6581

Auteurs

Julian Schütt (J)

Max Bergmann Center of Biomaterials and Institute for Materials Science, Dresden University of Technology, Budapesterstrasse 27, 01069 Dresden, Germany.
Institute of Ion Beam Physics and Materials Research, Helmholtz-Zentrum Dresden-Rossendorf e.V., Bautzner Landstrasse 400, 01328 Dresden, Germany.

Diana Isabel Sandoval Bojorquez (DI)

Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf e.V., Bautzner Landstrasse 400, 01328 Dresden, Germany.

Elisabetta Avitabile (E)

Department of Chemistry and Pharmacy, University of Sassari, via muroni 23, 07100 Sassari, Italy.

Eduardo Sergio Oliveros Mata (ES)

Max Bergmann Center of Biomaterials and Institute for Materials Science, Dresden University of Technology, Budapesterstrasse 27, 01069 Dresden, Germany.
Institute of Ion Beam Physics and Materials Research, Helmholtz-Zentrum Dresden-Rossendorf e.V., Bautzner Landstrasse 400, 01328 Dresden, Germany.

Gleb Milyukov (G)

Samsung R&D Institute Russia (SRR), 127018 Moscow, Russia.

Juliane Colditz (J)

Medizinische Klinik und Poliklinik III, Universitätsklinikum Carl Gustav Carus Dresden, 01307 Dresden, Germany.

Lucia Gemma Delogu (LG)

Department of Chemistry and Pharmacy, University of Sassari, via muroni 23, 07100 Sassari, Italy.
Department of Biomedical Sciences, University of Padua, via Ugo bassi 58, 35122 Padua, Italy.

Martina Rauner (M)

Medizinische Klinik und Poliklinik III, Universitätsklinikum Carl Gustav Carus Dresden, 01307 Dresden, Germany.

Anja Feldmann (A)

Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf e.V., Bautzner Landstrasse 400, 01328 Dresden, Germany.

Stefanie Koristka (S)

Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf e.V., Bautzner Landstrasse 400, 01328 Dresden, Germany.

Jan Moritz Middeke (JM)

Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus Dresden, 01307 Dresden, Germany.

Katja Sockel (K)

Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus Dresden, 01307 Dresden, Germany.

Jürgen Fassbender (J)

Institute of Ion Beam Physics and Materials Research, Helmholtz-Zentrum Dresden-Rossendorf e.V., Bautzner Landstrasse 400, 01328 Dresden, Germany.

Michael Bachmann (M)

Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf e.V., Bautzner Landstrasse 400, 01328 Dresden, Germany.

Martin Bornhäuser (M)

Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus Dresden, 01307 Dresden, Germany.
Else Kröner-Fresenius Center for Digital Health (EKFZ), Technische Universität Dresden (TU Dresden), Dresden, Germany.

Gianaurelio Cuniberti (G)

Max Bergmann Center of Biomaterials and Institute for Materials Science, Dresden University of Technology, Budapesterstrasse 27, 01069 Dresden, Germany.
Center for Advancing Electronics Dresden (cfaed), Technische Universität Dresden, 01069 Dresden, Germany.
Dresden Center for Computational Materials Science (DCMS), TU Dresden, 01062 Dresden, Germany.
Else Kröner-Fresenius Center for Digital Health (EKFZ), Technische Universität Dresden (TU Dresden), Dresden, Germany.
ORCID: 0000-0002-6574-7848

Larysa Baraban (L)

Max Bergmann Center of Biomaterials and Institute for Materials Science, Dresden University of Technology, Budapesterstrasse 27, 01069 Dresden, Germany.
Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf e.V., Bautzner Landstrasse 400, 01328 Dresden, Germany.
Center for Advancing Electronics Dresden (cfaed), Technische Universität Dresden, 01069 Dresden, Germany.
Else Kröner-Fresenius Center for Digital Health (EKFZ), Technische Universität Dresden (TU Dresden), Dresden, Germany.
ORCID: 0000-0003-1010-2791

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Nanocytometer for smart analysis of peripheral...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Leucémies › Leucémie myéloïde › Leucémie aigüe myéloïde › Nanocytometer for smart analysis of peripheral...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Nanocytometer for smart analysis of peripheral...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Monocytes › Nanocytometer for smart analysis of peripheral...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Projets pilotes › Nanocytometer for smart analysis of peripheral...