Identification of New Nitric Oxide-Donating Peptides with Dual Biofilm Eradication and Antibacterial Activities for Intervention of Device-Related Infections.

Amino Acid Sequence Animals Anti-Bacterial Agents / chemistry Antimicrobial Cationic Peptides / chemistry Biofilms / drug effects Cephalosporins / pharmacology Escherichia coli / physiology Hemolysis / drug effects Injections, Subcutaneous Mice Nitric Oxide / metabolism Nitric Oxide Donors / chemistry Staphylococcal Infections / drug therapy Staphylococcus aureus / physiology

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
10 09 2020
Historique:
pubmed: 14 8 2020
medline: 15 12 2020
entrez: 14 8 2020
Statut: ppublish

Résumé

Implantable medical device-related infections with biofilms have become a significant challenge in clinics. Based on the potential bacteria biofilm dispersing effect of nitric oxide (NO) and the unique antibacterial activity of antimicrobial peptides (AMP), we synthesized five peptides and selected the most potent one to conjugate its N-terminal with a furoxan moiety to offer a hitherto unknown NO-donating antimicrobial peptide (

Identifiants

DOI: 10.1021/acs.jmedchem.9b01832 PMID: 32787095
pubmed: 32787095
doi: 10.1021/acs.jmedchem.9b01832
doi:

Substances chimiques

Anti-Bacterial Agents 0
Antimicrobial Cationic Peptides 0
Cephalosporins 0
Nitric Oxide Donors 0
Nitric Oxide 31C4KY9ESH
cephalosporin C 3XIY7HJT5L

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

9127-9135

Auteurs

Yue Fei (Y)

Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, China Pharmaceutical University, Nanjing 210009, China.
CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beiyitiao No.11, Haidian District, Beijing, 100190, China.

Jianbing Wu (J)

Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, China Pharmaceutical University, Nanjing 210009, China.

Hong-Wei An (HW)

Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Yuquan Road, Beijing 100049, China.

Kai Zhu (K)

CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beiyitiao No.11, Haidian District, Beijing, 100190, China.

Bo Peng (B)

CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beiyitiao No.11, Haidian District, Beijing, 100190, China.

Junquan Cai (J)

CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beiyitiao No.11, Haidian District, Beijing, 100190, China.

Yihua Zhang (Y)

Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, China Pharmaceutical University, Nanjing 210009, China.
ORCID: 0000-0003-2378-7064

Li-Li Li (LL)

CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beiyitiao No.11, Haidian District, Beijing, 100190, China.
ORCID: 0000-0002-9793-3995

Hao Wang (H)

CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beiyitiao No.11, Haidian District, Beijing, 100190, China.
ORCID: 0000-0002-1961-0787

Zhangjian Huang (Z)

Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, China Pharmaceutical University, Nanjing 210009, China.
ORCID: 0000-0001-6409-8535

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Classifications MeSH

questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence d'acides aminés › Identification of New Nitric Oxide-Donating...
questionsmedicales.fr › Eucaryotes › Animaux › Identification of New Nitric Oxide-Donating...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Identification of New Nitric Oxide-Donating...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Perforines › Peptides antimicrobiens cationiques › Identification of New Nitric Oxide-Donating...
questionsmedicales.fr › Phénomènes microbiologiques › Biofilms › Identification of New Nitric Oxide-Donating...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › bêta-Lactames › Céphalosporines › Identification of New Nitric Oxide-Donating...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › Identification of New Nitric Oxide-Donating...
questionsmedicales.fr › Phénomènes du système immunitaire › Réaction antigène-anticorps › Hémolyse › Identification of New Nitric Oxide-Donating...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Injections › Injections sous-cutanées › Identification of New Nitric Oxide-Donating...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Identification of New Nitric Oxide-Donating...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Oxydes d'azote › Monoxyde d'azote › Identification of New Nitric Oxide-Donating...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents cardiovasculaires › Donneur d'oxyde nitrique › Identification of New Nitric Oxide-Donating...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram positif › Infections à staphylocoques › Identification of New Nitric Oxide-Donating...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Cocci à Gram positif › Staphylococcaceae › Staphylococcus › Staphylococcus aureus › Identification of New Nitric Oxide-Donating...