Efficient Colorectal Cancer Gene Therapy with IL-15 mRNA Nanoformulation.
3T3 Cells
Animals
Cell Line
Chemistry, Pharmaceutical
/ methods
Colonic Neoplasms
/ therapy
Disease Models, Animal
Female
HEK293 Cells
Humans
Interleukin-15
/ genetics
Liposomes
/ chemistry
Lymphocytes
/ drug effects
Mice
Mice, Inbred BALB C
Nanoparticles
/ chemistry
Neoplasm Metastasis
/ genetics
RNA, Messenger
/ genetics
IL-15
IVT mRNA
cancer gene therapy
gene delivery
Journal
Molecular pharmaceutics
ISSN: 1543-8392
Titre abrégé: Mol Pharm
Pays: United States
ID NLM: 101197791
Informations de publication
Date de publication:
08 09 2020
08 09 2020
Historique:
pubmed:
14
8
2020
medline:
7
7
2021
entrez:
14
8
2020
Statut:
ppublish
Résumé
Immunogene therapy is a novel method for the treatment of colorectal cancer. Cytokine IL-15 has exhibited therapeutic anticancer potential due to its immune-stimulation property. However, conventional IL-15-based cancer gene therapy studies have been performed using the plasmid DNA form, which has potential shortcomings including weak delivery efficiency and backbone effect. In this study, an IL-15 immunogene therapy study for colon cancer using
Identifiants
pubmed: 32787272
doi: 10.1021/acs.molpharmaceut.0c00451
doi:
Substances chimiques
IL15 protein, human
0
Interleukin-15
0
Liposomes
0
RNA, Messenger
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM