Direct or indirect regulation of muscle protein synthesis by energy status?
ATP
Amino acids
Energy status
Malnutrition
Muscle protein synthesis
Journal
Clinical nutrition (Edinburgh, Scotland)
ISSN: 1532-1983
Titre abrégé: Clin Nutr
Pays: England
ID NLM: 8309603
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
01
11
2019
revised:
10
04
2020
accepted:
14
07
2020
pubmed:
14
8
2020
medline:
2
9
2021
entrez:
14
8
2020
Statut:
ppublish
Résumé
Muscle protein synthesis (MPS) is a complex and finely-regulated mechanism that plays a key role in muscle homeostasis. Amino acid bioavailability is widely considered a major driver of MPS regulation via mTOR pathway activation. However, recent results suggest that amino acid bioavailability affects cellular energy status. Whatever the tool used to modulate energy status (amino acid depletion or mild mitochondrial uncoupling), a decrease in cellular energy status decreases MPS, without necessarily involving the mTOR pathway. Here we propose that energy status directly regulates one or several energy-consuming step(s) during MPS. This new paradigm modifies our vision of protein metabolism and raises prospects for new advances in therapeutics.
Identifiants
pubmed: 32788089
pii: S0261-5614(20)30380-0
doi: 10.1016/j.clnu.2020.07.015
pii:
doi:
Substances chimiques
Muscle Proteins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1893-1896Informations de copyright
Copyright © 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
Déclaration de conflit d'intérêts
Conflict of interest C. Moinard is a shareholder in Citrage. Eric Fontaine has no conflict of interest to report.