The African natural product knipholone anthrone and its analogue anthralin (dithranol) enhance HIV-1 latency reversal.

drug discovery drug-drug synergy histone deacetylase (HDAC) histone deacetylase inhibitor (HDAC inhibitor) (HDI) human immunodeficiency virus (HIV) latency reversal molecular pharmacology natural product protein kinase C (PKC) viral reservoirs

Journal

The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R

Informations de publication

Date de publication:
09 10 2020
Historique:
received: 12 02 2020
revised: 06 08 2020
pubmed: 14 8 2020
medline: 17 2 2021
entrez: 14 8 2020
Statut: ppublish

Résumé

A sterilizing or functional cure for HIV is currently precluded by resting CD4

Identifiants

pubmed: 32788215
pii: S0021-9258(17)49805-X
doi: 10.1074/jbc.RA120.013031
pmc: PMC7549037
doi:

Substances chimiques

Anthracenes 0
knipholone anthrone 0
Anthralin U8CJK0JH5M

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

14084-14099

Subventions

Organisme : NIAID NIH HHS
ID : UM1 AI126620
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS106970
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG062383
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK123733
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI143385
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI045008
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI129636
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS117458
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : CIHR
ID : PJT-153057
Pays : Canada
Organisme : CIHR
ID : PJT-159625
Pays : Canada
Organisme : Wellcome Trust
ID : 107752/Z/15/Z
Pays : United Kingdom

Informations de copyright

© 2020 Richard et al.

Déclaration de conflit d'intérêts

Conflict of interest—The authors declare that they have no conflicts of interest with the contents of this article.

Références

Skin Pharmacol. 1990;3(1):1-20
pubmed: 2202336
Curr Drug Targets. 2013 Jun 1;14(6):648-52
pubmed: 23547809
J Clin Invest. 2016 May 2;126(5):1630-9
pubmed: 27135880
Med Res Rev. 2020 May;40(3):881-908
pubmed: 31608481
Nature. 2012 Jul 25;487(7408):439-40
pubmed: 22836995
PLoS One. 2014 Jan 29;9(1):e84964
pubmed: 24489654
Nat Methods. 2012 Mar 04;9(4):357-9
pubmed: 22388286
PLoS One. 2015 Apr 01;10(4):e0121099
pubmed: 25830320
J Med Chem. 1992 May 29;35(11):1978-86
pubmed: 1597853
J Pharm Biomed Anal. 2019 Sep 10;174:277-285
pubmed: 31185339
J Clin Invest. 2015 May;125(5):1901-12
pubmed: 25822022
PLoS Pathog. 2015 Jul 30;11(7):e1005066
pubmed: 26225771
Curr Opin HIV AIDS. 2016 Jul;11(4):394-401
pubmed: 26974532
EMBO Mol Med. 2018 Feb;10(2):160-174
pubmed: 29246970
Nat Med. 2014 Apr;20(4):425-9
pubmed: 24658076
Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4819-24
pubmed: 12684537
J Ethnopharmacol. 2018 Jan 30;211:267-277
pubmed: 28970153
Virology. 1997 Oct 27;237(2):422-9
pubmed: 9356353
PLoS Pathog. 2015 Jul 30;11(7):e1005063
pubmed: 26225566
Science. 1997 Nov 14;278(5341):1291-5
pubmed: 9360926
Lancet. 2018 Aug 25;392(10148):685-697
pubmed: 30049419
Mucosal Immunol. 2020 Sep;13(5):753-766
pubmed: 32152415
J Virol. 2017 May 12;91(11):
pubmed: 28331083
Genet Mol Res. 2012 Feb 17;11(1):412-20
pubmed: 22370944
J Virol. 2002 Aug;76(16):8118-23
pubmed: 12134017
Genome Biol. 2014;15(12):550
pubmed: 25516281
PLoS Pathog. 2009 Jun;5(6):e1000495
pubmed: 19557157
Retrovirology. 2009 Jun 02;6:52
pubmed: 19486542
EMBO J. 2003 Apr 15;22(8):1868-77
pubmed: 12682019
Cell Mol Life Sci. 2019 Sep;76(18):3583-3600
pubmed: 31129856
Behav Brain Res. 2001 Nov 1;125(1-2):279-84
pubmed: 11682119
Antiviral Res. 2019 Jun;166:19-34
pubmed: 30914265
Nat Med. 2003 Jun;9(6):727-8
pubmed: 12754504
Clin Med Insights Pathol. 2017 Mar 10;10:1179555717694535
pubmed: 28469516
PLoS One. 2014 Mar 05;9(3):e90655
pubmed: 24599120
Science. 1997 Nov 14;278(5341):1295-300
pubmed: 9360927
BMC Bioinformatics. 2011 Aug 04;12:323
pubmed: 21816040
Planta Med. 1999 Dec;65(8):757-8
pubmed: 10630123
Viruses. 2018 Jun 27;10(7):
pubmed: 29954099
PLoS Pathog. 2016 Jun 02;12(6):e1005677
pubmed: 27253379
J Biol Chem. 2004 Oct 1;279(40):42008-17
pubmed: 15284245
Gen Pharmacol. 1996 Dec;27(8):1325-35
pubmed: 9304402
J Virol. 1991 Sep;65(9):4645-53
pubmed: 1678437
J Virol. 2016 Sep 29;90(20):9495-508
pubmed: 27512074
Food Chem Toxicol. 2009 Jul;47(7):1490-4
pubmed: 19345716
Nat Prod Rep. 2008 Aug;25(4):696-718
pubmed: 18663391
Curr Opin Virol. 2019 Oct;38:1-9
pubmed: 31048093
J Clin Invest. 2009 Nov;119(11):3473-86
pubmed: 19805909

Auteurs

Khumoekae Richard (K)

Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.

Cole Schonhofer (C)

Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.

Leila B Giron (LB)

Wistar Institute, Philadelphia, Pennsylvania, USA.

Jocelyn Rivera-Ortiz (J)

Wistar Institute, Philadelphia, Pennsylvania, USA.

Silven Read (S)

Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.

Toshitha Kannan (T)

Wistar Institute, Philadelphia, Pennsylvania, USA.

Natalie N Kinloch (NN)

Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.
British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.

Aniqa Shahid (A)

Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.
British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.

Ruth Feilcke (R)

Institut für Pharmazie, Martin-Luther-Universität Halle-Wittenberg, Halle, Germany.

Simone Wappler (S)

Institut für Pharmazie, Martin-Luther-Universität Halle-Wittenberg, Halle, Germany.

Peter Imming (P)

Institut für Pharmazie, Martin-Luther-Universität Halle-Wittenberg, Halle, Germany.

Marianne Harris (M)

British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.

Zabrina L Brumme (ZL)

Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.
British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.

Mark A Brockman (MA)

Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.
British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.
Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada.

Karam Mounzer (K)

Jonathan Lax Immune Disorders Treatment Center, Philadelphia Field Initiating Group for HIV-1 Trials, Philadelphia, Pennsylvania, USA.

Andrew V Kossenkov (AV)

Wistar Institute, Philadelphia, Pennsylvania, USA.

Mohamed Abdel-Mohsen (M)

Wistar Institute, Philadelphia, Pennsylvania, USA.

Kerstin Andrae-Marobela (K)

Department of Biological Sciences, University of Botswana, Gaborone, Botswana.

Luis J Montaner (LJ)

Wistar Institute, Philadelphia, Pennsylvania, USA.

Ian Tietjen (I)

Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada itietjen@wistar.org.
Wistar Institute, Philadelphia, Pennsylvania, USA.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH