Mitofusin 2 regulates neutrophil adhesive migration and the actin cytoskeleton.

Actin Cytoskeleton Adhesives Animals Cell Movement Mice Neutrophils Zebrafish
Actin Chemotaxis Leukocyte Mitochondria Rac Zebrafish

Journal

Journal of cell science
ISSN: 1477-9137
Titre abrégé: J Cell Sci
Pays: England
ID NLM: 0052457

Informations de publication

Date de publication:
04 09 2020
Historique:
received: 12 05 2020
accepted: 29 07 2020
pubmed: 14 8 2020
medline: 22 6 2021
entrez: 14 8 2020
Statut: epublish

Résumé

Neutrophils rely on glycolysis for energy production. How mitochondria regulate neutrophil function is not fully understood. Here, we report that mitochondrial outer membrane protein Mitofusin 2 (MFN2) regulates neutrophil homeostasis and chemotaxis

Identifiants

DOI: 10.1242/jcs.248880 PMID: 32788232 PMC: PMC7491649
pubmed: 32788232
pii: jcs.248880
doi: 10.1242/jcs.248880
pmc: PMC7491649
pii:
doi:

Substances chimiques

Adhesives 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NICHD NIH HHS
ID : R01 HD073156
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM119787
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM132501
Pays : United States
Organisme : NIH HHS
ID : S10 OD020029
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA023168
Pays : United States

Informations de copyright

© 2020. Published by The Company of Biologists Ltd.

Déclaration de conflit d'intérêts

Competing interestsThe authors declare no competing or financial interests.

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Auteurs

Wenqing Zhou (W)

Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA.

Alan Y Hsu (AY)

Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA.
ORCID: 0000-0001-5680-345X

Yueyang Wang (Y)

Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA.
ORCID: 0000-0002-5445-8186

Ramizah Syahirah (R)

Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA.

Tianqi Wang (T)

Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA.

Jacob Jeffries (J)

Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA.

Xu Wang (X)

Department of Agricultural & Biological Engineering, Purdue University, West Lafayette, IN 47907, USA.
Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.

Haroon Mohammad (H)

Department of Comparative Pathobiology, Purdue University, West Lafayette, IN 47907, USA.

Mohamed N Seleem (MN)

Department of Comparative Pathobiology, Purdue University, West Lafayette, IN 47907, USA.
Purdue Institute for Inflammation, Immunology & Infectious Disease, Purdue University, West Lafayette, IN 47907, USA.

David Umulis (D)

Department of Agricultural & Biological Engineering, Purdue University, West Lafayette, IN 47907, USA.
Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.

Qing Deng (Q)

Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA deng67@purdue.edu.
Purdue Institute for Inflammation, Immunology & Infectious Disease, Purdue University, West Lafayette, IN 47907, USA.
Purdue University Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA.
ORCID: 0000-0002-9254-9951

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Classifications MeSH

questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Cytosquelette › Cytosquelette d'actine › Mitofusin 2 regulates neutrophil adhesive...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Adhésifs › Mitofusin 2 regulates neutrophil adhesive...
questionsmedicales.fr › Eucaryotes › Animaux › Mitofusin 2 regulates neutrophil adhesive...
questionsmedicales.fr › Phénomènes physiologiques › Mouvement cellulaire › Mitofusin 2 regulates neutrophil adhesive...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Mitofusin 2 regulates neutrophil adhesive...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Granulocytes neutrophiles › Mitofusin 2 regulates neutrophil adhesive...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Cypriniformes › Cyprinidae › Danio zébré › Mitofusin 2 regulates neutrophil adhesive...