Osteoporosis: Pathophysiology and therapeutic options.
gut microbiome
osteoimmunology
osteoporosis
osteoporosis treatment
pathophysiology
senescence
Journal
EXCLI journal
ISSN: 1611-2156
Titre abrégé: EXCLI J
Pays: Germany
ID NLM: 101299402
Informations de publication
Date de publication:
2020
2020
Historique:
received:
29
06
2020
accepted:
07
07
2020
entrez:
14
8
2020
pubmed:
14
8
2020
medline:
14
8
2020
Statut:
epublish
Résumé
Osteoporosis is a metabolic bone disease that, on a cellular level, results from osteoclastic bone resorption not compensated by osteoblastic bone formation. This causes bones to become weak and fragile, thus increasing the risk of fractures. Traditional pathophysiological concepts of osteoporosis focused on endocrine mechanisms such as estrogen or vitamin D deficiency as well as secondary hyperparathyroidism. However, research over the last decades provided exiting new insights into mechanisms contributing to the onset of osteoporosis, which go far beyond this. Selected mechanisms such as interactions between bone and the immune system, the gut microbiome, and cellular senescence are reviewed in this article. Furthermore, an overview on currently available osteoporosis medications including antiresorptive and bone forming drugs is provided and an outlook on potential future treatment options is given.
Identifiants
pubmed: 32788914
doi: 10.17179/excli2020-2591
pii: 2020-2591
pii: Doc1017
pmc: PMC7415937
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1017-1037Informations de copyright
Copyright © 2020 Föger-Samwald et al.
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