Cell-Derived Microparticles in Blood Products from Thalassemic Blood Donors.
flow cytometry
laboratory
microparticle
quantitation
transfusion donor
β-thalassemia
Journal
Laboratory medicine
ISSN: 1943-7730
Titre abrégé: Lab Med
Pays: England
ID NLM: 0250641
Informations de publication
Date de publication:
15 Mar 2021
15 Mar 2021
Historique:
pubmed:
14
8
2020
medline:
16
10
2021
entrez:
14
8
2020
Statut:
ppublish
Résumé
To determine the number of cell-derived microparticles (MPs) in blood products obtained from donors who have thalassemia. Packed red blood cells (PRBCs), plasma, and platelet concentrate (PC) were prepared according to routine procedures. We used flow cytometry to quantitate the concentration of MPs. The results of a comparison of MP levels in unprocessed whole blood showed that the concentration of all MPs in the donors without thalassemia trait (n = 255) was higher than in donors with thalassemia trait (n = 70). After processing, increased concentrations of MPs were documented in both groups. Among the blood components, PRBC showed higher platelet-derived MP concentrations in donors with thalassemia than in donors without thalassemia. However, PC showed higher concentrations of total MPs in donors without thalassemia than in donors with that condition. Our results suggest little influence of thalassemia-trait status on changes in MP concentrations in blood components.
Identifiants
pubmed: 32789465
pii: 5892002
doi: 10.1093/labmed/lmaa041
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
150-157Informations de copyright
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