Probe-Free Direct Identification of Type I and Type II Photosensitized Oxidation Using Field-Induced Droplet Ionization Mass Spectrometry.
field-induced droplet ionization
lipid oxidation
mass spectrometry
photodynamic therapy
type I and II mechanism
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
23 Nov 2020
23 Nov 2020
Historique:
received:
28
07
2020
pubmed:
14
8
2020
medline:
14
8
2020
entrez:
14
8
2020
Statut:
ppublish
Résumé
While Type I and Type II photosensitizers are often carefully tailored to achieve their respective advantages in treating different cancers, the identifications of the Type I and II mechanisms as such, the key reaction intermediates, and the consequent oxidation products of the substrates have never been easy. Using our unique home-built field-induced droplet ionization mass spectrometry (FIDI-MS) method that selectively samples molecules at the air-water interface, here we show the facile determination of both Type I and II mechanisms of a poster-child photosensitizer, temoporfin, without the addition of any probes. The unstable doublet radical resulting from the hydrogen abstraction by the triplet temoporfin through the Type I mechanism is captured, manifesting the in situ advantage of FIDI-MS. We anticipate that the method developed in this study can be widely utilized in the future designs of novel photosensitizers and the screening of their photosensitization mechanisms.
Identifiants
pubmed: 32790010
doi: 10.1002/anie.202010294
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
21515-21519Subventions
Organisme : National Key R&D Program of China
ID : 2018YFE0115000
Organisme : NSF of Tianjin City
ID : 19JCYBJC19600
Informations de copyright
© 2020 Wiley-VCH GmbH.
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