The role of the corpus callosum in language network connectivity in children.
corpus callosum
functional imaging
language development
language network
Journal
Developmental science
ISSN: 1467-7687
Titre abrégé: Dev Sci
Pays: England
ID NLM: 9814574
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
16
10
2019
revised:
15
05
2020
accepted:
07
08
2020
pubmed:
14
8
2020
medline:
24
4
2021
entrez:
14
8
2020
Statut:
ppublish
Résumé
The specific role of the corpus callosum (CC) in language network organization remains unclear, two contrasting models have been proposed: inhibition of homotopic areas allowing for independent functioning of the hemispheres versus integration of information from both hemispheres. This study aimed to add to this discussion with the first investigation of language network connectivity in combination with CC volume measures. In 38 healthy children aged 6-12, we performed task-based functional magnetic resonance imaging to measure language network connectivity, used structural magnetic resonance imaging to quantify CC subsection volumes, and administered various language tests to examine language abilities. We found an increase in left intrahemispheric and bilateral language network connectivity and a decrease in right intrahemispheric connectivity associated with larger volumes of the posterior, mid-posterior, and central subsections of the CC. Consistent with that, larger volumes of the posterior parts of the CC were significantly associated with better verbal fluency and vocabulary, the anterior CC volume was positively correlated with verbal span. Thus, children with larger volumes of CC subsections showed increased interhemispheric language network connectivity and were better in different language domains. This study presents the first evidence that the CC is directly linked to language network connectivity and underlines the excitatory role of the CC in the integration of information from both hemispheres.
Identifiants
pubmed: 32790079
doi: 10.1111/desc.13031
pmc: PMC7988581
mid: EMS118962
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13031Subventions
Organisme : Austrian Science Fund FWF
ID : KLI 544
Pays : Austria
Informations de copyright
© 2020 The Authors. Developmental Science published by John Wiley & Sons Ltd.
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