Mental development is associated with cortical connectivity of the ventral and nonspecific thalamus of preterm newborns.
mental development
neurodevelopment
newborn
nonspecific thalamus
preterm
thalamocortical tracts
thalamus
ventral thalamus
Journal
Brain and behavior
ISSN: 2162-3279
Titre abrégé: Brain Behav
Pays: United States
ID NLM: 101570837
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
07
10
2019
revised:
18
06
2020
accepted:
19
07
2020
pubmed:
14
8
2020
medline:
25
6
2021
entrez:
14
8
2020
Statut:
ppublish
Résumé
The thalamus is a key hub for regulating cortical connectivity. Dysmaturation of thalamocortical networks that accompany white matter injury has been hypothesized as neuroanatomical correlate of late life neurocognitive impairment following preterm birth. Our objective was to find a link between thalamocortical connectivity measures at term equivalent age and two-year neurodevelopmental outcome in preterm infants. Diffusion tensor MRI data of 58 preterm infants (postmenstrual age at birth, mean (SD), 29.71 (1.47) weeks) were used in the study. We utilized probabilistic diffusion tractography to trace connections between the cortex and thalami. Possible associations between connectivity strength, the length of the probabilistic fiber pathways, and developmental scores (Bayley Scales of Infant Development, Second Edition) were analyzed using multivariate linear regression models. We found strong correlation between mental developmental index and two complementary measures of thalamocortical networks: Connectivity strength projected to a cortical skeleton and pathway length emerging from thalamic voxels (partial correlation, R = .552 and R = .535, respectively, threshold-free cluster enhancement, corrected p-value < .05), while psychomotor development was not associated with thalamocortical connectivity. Post hoc stepwise linear regression analysis revealed that parental socioeconomic scale, postmenstrual age, and the duration of mechanical ventilation at the intensive care unit contribute to the variability of outcome. Our findings independently validated previous observations in preterm infants, providing additional evidence injury or dysmaturation of tracts emerging from ventral-specific and various nonspecific thalamus projecting to late-maturing cortical regions are predictive of mental, but not psychomotor developmental outcomes.
Identifiants
pubmed: 32790242
doi: 10.1002/brb3.1786
pmc: PMC7559616
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e01786Subventions
Organisme : Foundation for Research in Science and the Humanities at the University of Zurich
Organisme : EMDO Stiftung
Organisme : Forschungszentrum für das Kind (FZK)
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
ID : 3200B0-108176
Organisme : Anna Müller Grocholski Foundation
Organisme : OPO Foundation
Organisme : Uniscientia Foundation
Organisme : Prof. Dr. Max Cloetta Foundation
Informations de copyright
© 2020 The Authors. Brain and Behavior published by Wiley Periodicals LLC.
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