Isochronal Conditions-The Key To Maintain the Given Solubility Limit, of a Small Molecule within the Polymer Matrix, at Elevated Pressure.
ASD
Kollidon VA64
dielectric spectroscopy
flutamide
high-pressure
solubility
Journal
Molecular pharmaceutics
ISSN: 1543-8392
Titre abrégé: Mol Pharm
Pays: United States
ID NLM: 101197791
Informations de publication
Date de publication:
05 10 2020
05 10 2020
Historique:
pubmed:
14
8
2020
medline:
3
8
2021
entrez:
14
8
2020
Statut:
ppublish
Résumé
In this work, we proposed the method to maintain the desired level of drug's solubility within the polymer matrix by adjusting conditions to uphold the same molecular dynamics of the system (e.g., temperature for set elevated pressure or vice versa). Namely, we observed, that recrystallization of the drug from the supersaturated drug-polymer system, initiated for the same structural relaxation time of the sample (τ
Identifiants
pubmed: 32790413
doi: 10.1021/acs.molpharmaceut.0c00463
pmc: PMC7539297
doi:
Substances chimiques
Polymers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3730-3739Références
Eur J Pharm Biopharm. 2018 Mar;124:147-157
pubmed: 29269154
Eur J Pharm Sci. 2016 Mar 31;85:10-7
pubmed: 26826280
Mol Pharm. 2017 Aug 7;14(8):2670-2680
pubmed: 28692796
Mol Pharm. 2019 Apr 1;16(4):1742-1750
pubmed: 30848603
Eur J Pharm Sci. 2019 Aug 1;136:104947
pubmed: 31170526
J Pharm Sci. 2011 Aug;100(8):3196-3207
pubmed: 21416468
Mol Pharm. 2017 Oct 2;14(10):3370-3380
pubmed: 28787567
Mol Pharm. 2014 Apr 7;11(4):1102-8
pubmed: 24533914
Pharm Res. 2009 Jan;26(1):139-51
pubmed: 18779927
Eur J Pharm Biopharm. 2019 Mar;136:231-239
pubmed: 30703545
J Phys Chem B. 2009 Sep 17;113(37):12536-45
pubmed: 19694472
Pharm Res. 2006 Oct;23(10):2417-26
pubmed: 16933098
Eur J Pharm Biopharm. 2012 May;81(1):207-13
pubmed: 22293573
J Pharm Sci. 2010 Sep;99(9):4023-31
pubmed: 20607809
Mol Pharm. 2015 Oct 5;12(10):3628-38
pubmed: 26323061
Mol Pharm. 2018 Nov 5;15(11):5327-5335
pubmed: 30259745
Mol Pharm. 2013 Jan 7;10(1):236-48
pubmed: 23110477
Mol Pharm. 2017 Apr 3;14(4):1154-1168
pubmed: 28241116
AAPS PharmSciTech. 2018 Jan;19(1):358-370
pubmed: 28741140
Mol Pharm. 2018 Nov 5;15(11):5192-5206
pubmed: 30252481
Eur J Pharm Biopharm. 2019 Oct;143:8-17
pubmed: 31398439
Mol Pharm. 2016 Jun 6;13(6):1937-46
pubmed: 27149568
Pharm Res. 2009 Apr;26(4):855-64
pubmed: 19052850
Mol Pharm. 2013 Feb 4;10(2):560-6
pubmed: 23253068
Mol Pharm. 2016 Apr 4;13(4):1308-16
pubmed: 26981876
J Pharm Sci. 1999 Nov;88(11):1182-90
pubmed: 10564068
J Pharm Sci. 2010 Jul;99(7):2941-7
pubmed: 20127825
Phys Chem Chem Phys. 2019 Jan 2;21(2):702-717
pubmed: 30543221
Eur J Pharm Sci. 2018 Mar 1;114:356-363
pubmed: 29309874
Int J Pharm. 2017 Mar 15;519(1-2):44-57
pubmed: 28063904
Eur J Pharm Biopharm. 2018 Nov;132:112-126
pubmed: 30248394
J Phys Chem B. 2010 May 20;114(19):6579-93
pubmed: 20415466
Mol Pharm. 2016 Mar 7;13(3):756-65
pubmed: 26866895