Effects of nutritional supplements on the re-infection rate of soil-transmitted helminths in school-age children: A systematic review and meta-analysis.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2020
2020
Historique:
received:
01
04
2020
accepted:
20
07
2020
entrez:
14
8
2020
pubmed:
14
8
2020
medline:
10
10
2020
Statut:
epublish
Résumé
The effect of nutritional supplements on the re-infection rate of species-specific soil-transmitted helminth infections in school-aged children remains complex and available evidence on the subject matter has not been synthesized. The review included randomised controlled trials (RCTs) and cluster RCTs investigating food supplements on school-aged children between the age of 4-17 years. A search for RCTs was conducted on eight databases from inception to 12th June 2019. Cochrane Risk of Bias tool was used to assess the risk of bias in all included studies. Meta-analysis and narrative synthesis were conducted to describe and analyze the results of the review. Outcomes were summarized using the mean difference or standardized mean difference where appropriate. The search produced 1,816 records. Six studies met the inclusion criteria (five individually RCTs and one cluster RCT). Four studies reported data on all three STH species, while one study only reported data on Ascaris lumbricoides infections and the last study reported data on only hookworm infections. Overall, the risk of bias in four individual studies was low across most domains. Nutritional supplementation failed to statistically reduce the re-infection rates of the three STH species. The effect of nutritional supplements on measures of physical wellbeing in school-aged children could not be determined. The findings from this systematic review suggest that nutritional supplements for treatment of STH in children should not be encouraged unless better evidence emerges. Conclusion of earlier reviews on general populations may not necessarily apply to children since children possibly have a higher re-infection rate.
Sections du résumé
BACKGROUND
The effect of nutritional supplements on the re-infection rate of species-specific soil-transmitted helminth infections in school-aged children remains complex and available evidence on the subject matter has not been synthesized.
METHODS
The review included randomised controlled trials (RCTs) and cluster RCTs investigating food supplements on school-aged children between the age of 4-17 years. A search for RCTs was conducted on eight databases from inception to 12th June 2019. Cochrane Risk of Bias tool was used to assess the risk of bias in all included studies. Meta-analysis and narrative synthesis were conducted to describe and analyze the results of the review. Outcomes were summarized using the mean difference or standardized mean difference where appropriate.
RESULTS
The search produced 1,816 records. Six studies met the inclusion criteria (five individually RCTs and one cluster RCT). Four studies reported data on all three STH species, while one study only reported data on Ascaris lumbricoides infections and the last study reported data on only hookworm infections. Overall, the risk of bias in four individual studies was low across most domains. Nutritional supplementation failed to statistically reduce the re-infection rates of the three STH species. The effect of nutritional supplements on measures of physical wellbeing in school-aged children could not be determined.
CONCLUSIONS
The findings from this systematic review suggest that nutritional supplements for treatment of STH in children should not be encouraged unless better evidence emerges. Conclusion of earlier reviews on general populations may not necessarily apply to children since children possibly have a higher re-infection rate.
Identifiants
pubmed: 32790693
doi: 10.1371/journal.pone.0237112
pii: PONE-D-20-08643
pmc: PMC7425883
doi:
Substances chimiques
Micronutrients
0
Soil
0
Vitamins
0
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0237112Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Trop Med Int Health. 2013 Aug;18(8):942-51
pubmed: 23837404
BMJ. 2014 Dec 19;349:g7731
pubmed: 25527114
Trans R Soc Trop Med Hyg. 2000 Sep-Oct;94(5):493-9
pubmed: 11132373
Pan Afr Med J. 2018 May 29;30:74
pubmed: 30344858
PLoS Med. 2012 Jan;9(1):e1001162
pubmed: 22291577
Trends Parasitol. 2003 Dec;19(12):547-51
pubmed: 14642761
PLoS Negl Trop Dis. 2018 Mar 01;12(3):e0006213
pubmed: 29494581
Matern Child Nutr. 2008 Apr;4 Suppl 1:118-236
pubmed: 18289159
Eur Respir J. 2008 Nov;32(5):1141-3
pubmed: 18978131
PLoS One. 2017 Aug 10;12(8):e0182951
pubmed: 28797115
Behav Ther. 2017 Jul;48(4):567-580
pubmed: 28577591
Clin Infect Dis. 2008 May 15;46(10):1582-8
pubmed: 18419494
PLoS Negl Trop Dis. 2012;6(5):e1621
pubmed: 22590656
Parasit Vectors. 2014 May 19;7:229
pubmed: 24885622
Am J Clin Nutr. 2014 Jun;99(6):1499-509
pubmed: 24740209
Am J Trop Med Hyg. 2013 Jul;89(1):23-31
pubmed: 23690551
Trans R Soc Trop Med Hyg. 2003 Jan-Feb;97(1):109-14
pubmed: 12886816
J Trop Med. 2018 Apr 4;2018:6706413
pubmed: 29849666
Pediatr Infect Dis J. 2019 Aug;38(8):e175-e177
pubmed: 31306401
Annu Rev Nutr. 2001;21:297-321
pubmed: 11375439
Pediatr Allergy Immunol. 2010 Jun;21(4 Pt 1):564-76
pubmed: 20337968
PLoS One. 2016 Jan 06;11(1):e0145351
pubmed: 26735845
Parasit Vectors. 2019 Feb 7;12(1):76
pubmed: 30732642
Int J Epidemiol. 2018 Feb 1;47(1):321-331
pubmed: 29025158
BMJ. 2011 Oct 18;343:d5928
pubmed: 22008217
PLoS Med. 2014 Mar 25;11(3):e1001620
pubmed: 24667810
Lancet. 2018 Jan 20;391(10117):252-265
pubmed: 28882382
Trans R Soc Trop Med Hyg. 2009 Mar;103(3):229-36
pubmed: 18937957
Parasit Vectors. 2014 Aug 15;7:367
pubmed: 25127885
BMC Med Res Methodol. 2019 Jan 11;19(1):16
pubmed: 30634920
BMC Public Health. 2007 Nov 27;7:342
pubmed: 18042287
Int J Environ Res Public Health. 2011 Apr;8(4):1174-205
pubmed: 21695035