RE-PERG in early-onset Alzheimer's disease: A double-blind, electrophysiological pilot study.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2020
2020
Historique:
received:
18
11
2019
accepted:
08
07
2020
entrez:
14
8
2020
pubmed:
14
8
2020
medline:
29
9
2020
Statut:
epublish
Résumé
To evaluate the ability of re-test pattern electroretinogram (RE-PERG), a non-invasive and fast steady-state PERG, to detect inner retinal bioelectric function anomalies in patients with early-onset Alzheimer's disease (AD). The study population consisted of 17 patients with AD-related mild cognitive impairment (MCI), 16 patients with vascular dementia (VD)-related MCI, both assessed using the neuropsychological Mini-Mental State Examination (MMSE) and by structural magnetic resonance imaging, and 19 healthy, age-matched normal controls (NC). All participants were visually asymptomatic, had normal or near-normal general cognitive functioning and no or minimal impairments in daily life activities. Visual field (VF) test, optical coherence tomography (OCT) and RE-PERG, sampled in five consecutive blocks of 130 events, were performed. There was no statistically significant difference among the three groups with respect to age, VF parameters (mean and pattern standard deviations) and OCT parameters (ganglion cell complex thickness and retinal nerve fiber layer thickness). The mean amplitude in the RE-PERG was significantly lower, but only weakly in the AD group than in NC (p = 0.1) whereas the intrinsic variability of the 2nd harmonic phase was significantly higher in the AD group than in either the VD or NC group (p<0.001). RE-PERG is altered in early-stage AD, showing a reduced amplitude with high intrinsic phase variability. It also allows the discrimination of AD from VD. A high intrinsic variability in the PERG signal, determined using RE-PERG, may thus be a new promising test for neurodegenerative diseases.
Identifiants
pubmed: 32790788
doi: 10.1371/journal.pone.0236568
pii: PONE-D-19-31892
pmc: PMC7425894
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0236568Déclaration de conflit d'intérêts
The Authors have declared that no competing interest exist.
Références
Arch Ophthalmol. 1989 Jan;107(1):81-6
pubmed: 2642703
J Int Neuropsychol Soc. 2012 Nov;18(6):1031-40
pubmed: 22676901
J Neurosci. 1987 Jun;7(6):1799-808
pubmed: 2439665
Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13444-9
pubmed: 17684098
Neurology. 1995 Jan;45(1):68-74
pubmed: 7824139
Doc Ophthalmol. 1988 Sep;70(1):117-22
pubmed: 3229289
Brain Res Bull. 2010 May 31;82(3-4):169-76
pubmed: 20385208
J Glaucoma. 2010 Apr-May;19(4):243-7
pubmed: 19528818
Neurol Clin. 2016 Nov;34(4):941-953
pubmed: 27720002
Br J Ophthalmol. 2018 Feb;102(2):233-237
pubmed: 28600299
Stroke. 2011 Sep;42(9):2672-713
pubmed: 21778438
Science. 1981 Feb 27;211(4485):953-5
pubmed: 7466369
J Neurosci. 2013 Oct 30;33(44):17444-57
pubmed: 24174678
J Psychiatr Res. 1975 Nov;12(3):189-98
pubmed: 1202204
Neural Plast. 2018 Oct 14;2018:2941783
pubmed: 30405709
J Alzheimers Dis. 2016 Sep 6;54(2):585-95
pubmed: 27567815
Arch Gen Psychiatry. 2007 Aug;64(8):966-74
pubmed: 17679641
Int Ophthalmol. 2014 Dec;34(6):1203-11
pubmed: 25284015
Invest Ophthalmol Vis Sci. 2007 May;48(5):2285-9
pubmed: 17460292
Vision Res. 1997 Dec;37(24):3609-25
pubmed: 9425534
Clin Ophthalmol. 2017 Jan 23;11:209-218
pubmed: 28176965
Curr Opin Neurol. 2009 Feb;22(1):3-10
pubmed: 19155758
Invest Ophthalmol Vis Sci. 2006 Sep;47(9):3904-11
pubmed: 16936103
Nippon Ganka Gakkai Zasshi. 2012 Jan;116(1):3-46
pubmed: 22352070
J Intern Med. 2004 Sep;256(3):183-94
pubmed: 15324362
Ophthalmic Res. 2019;62(1):46-54
pubmed: 31104053
Alzheimers Dement (N Y). 2019 Oct 09;5:570-578
pubmed: 31650013
Graefes Arch Clin Exp Ophthalmol. 2008 Aug;246(8):1153-62
pubmed: 18386035
Doc Ophthalmol. 2010 Oct;121(2):111-21
pubmed: 20549299
Biomed Res Int. 2015;2015:571314
pubmed: 26167489
Alzheimers Dement. 2011 May;7(3):270-9
pubmed: 21514249
Brain. 1998 Feb;121 ( Pt 2):303-16
pubmed: 9549508
Br J Ophthalmol. 2014 Mar;98(3):408-12
pubmed: 24357496
Neurosci Lett. 2011 Mar 17;491(2):122-6
pubmed: 21236314
Am J Ophthalmol. 2002 Jan;133(1):135-7
pubmed: 11755850
Folia Neuropathol. 2005;43(3):133-8
pubmed: 16245206
Geriatrics. 1991 Jul;46(7):54-8, 63, 66
pubmed: 2060803
Neurobiol Aging. 2018 Jul;67:181-188
pubmed: 29735432
Optom Vis Sci. 2008 Jun;85(6):386-95
pubmed: 18521020
Arch Neurol. 1999 Mar;56(3):303-8
pubmed: 10190820
Ophthalmology. 1990 Jan;97(1):9-17
pubmed: 2314849
Eye Contact Lens. 2009 Sep;35(5):238-41
pubmed: 19672200
Clin Neurophysiol. 2000 Sep;111(9):1582-8
pubmed: 10964068
Ann Neurol. 1989 Aug;26(2):226-31
pubmed: 2774510
Ann Neurol. 2016 Jan;79(1):90-109
pubmed: 26505992
Invest Ophthalmol Vis Sci. 2014 Feb 04;55(2):696-705
pubmed: 24425856
Invest Ophthalmol Vis Sci. 2005 Apr;46(4):1296-302
pubmed: 15790894
Neurobiol Aging. 1994 Jan-Feb;15(1):29-43
pubmed: 8159261
Prim Care Companion J Clin Psychiatry. 2005;7(2):62-69
pubmed: 15841197
Biomed Res Int. 2017;2017:3079141
pubmed: 29392131
Ann Neurol. 1989 Aug;26(2):221-5
pubmed: 2774509
Eye (Lond). 2020 Mar;34(3):562-571
pubmed: 31409906
JAMA Neurol. 2018 Oct 1;75(10):1256-1263
pubmed: 29946702
Brain Res. 2008 Jun 5;1213:152-65
pubmed: 18455153
Invest Ophthalmol Vis Sci. 2017 Mar 1;58(3):1637-1645
pubmed: 28297029
Am J Hum Genet. 2001 Aug;69(2):447-53
pubmed: 11438888
Stroke. 2012 Sep;43(9):2526-34
pubmed: 22879100
J Cell Biol. 2005 Oct 24;171(2):313-25
pubmed: 16247030
Neurosci Lett. 2010 Aug 9;480(1):69-72
pubmed: 20609426
Alzheimers Dement (Amst). 2018 Feb 07;10:196-209
pubmed: 29780864
Ophthalmology. 2004 Jan;111(1):161-8
pubmed: 14711729
Acta Ophthalmol Scand. 2001 Apr;79(2):187-91
pubmed: 11284761
Neurology. 1993 Nov;43(11):2328-30
pubmed: 8232951
Ann Neurol. 1981 Aug;10(2):122-6
pubmed: 7283399
Neurobiol Aging. 2011 Mar;32(3):419-33
pubmed: 19356824
Clin Neurophysiol. 2001 Oct;112(10):1860-7
pubmed: 11595144
Mol Neurobiol. 2019 Aug;56(8):5416-5435
pubmed: 30612332
Neuropathol Appl Neurobiol. 1995 Oct;21(5):410-22
pubmed: 8632836
J Comp Neurol. 1990 Nov 1;301(1):55-64
pubmed: 1706358
PLoS One. 2019 Aug 15;14(8):e0220535
pubmed: 31415594
Ger J Ophthalmol. 1992;1(1):35-40
pubmed: 1477616
J Geriatr Psychiatry Neurol. 2007 Dec;20(4):227-38
pubmed: 18004009
Am J Ophthalmol. 1987 Aug 15;104(2):113-20
pubmed: 3618708
J Glaucoma. 2009 Sep;18(7):535-42
pubmed: 19745668
Surv Ophthalmol. 2001 May-Jun;45(6):516-24
pubmed: 11425357
Ophthalmology. 2005 Jan;112(1):10-9
pubmed: 15629814
Brain Res Brain Res Rev. 2000 Nov;34(1-2):42-68
pubmed: 11086186
Invest Ophthalmol Vis Sci. 2019 Aug 1;60(10):3447-3455
pubmed: 31408108
Optom Vis Sci. 1995 Feb;72(2):83-91
pubmed: 7753532
Neurology. 1997 Nov;49(5):1322-30
pubmed: 9371916
Neurology. 2006 Nov 28;67(10):1852-4
pubmed: 17130422
Eur Neurol. 2002;47(3):165-8
pubmed: 11914555
J Neurosci. 1990 Feb;10(2):649-69
pubmed: 2303866
Invest Ophthalmol Vis Sci. 2003 Feb;44(2):875-8
pubmed: 12556424
J Alzheimers Dis. 2009;17(2):305-18
pubmed: 19363264
J Neurocytol. 2004 Sep;33(5):517-33
pubmed: 15906159
Radiology. 2012 May;263(2):344-61
pubmed: 22517954
Invest Ophthalmol Vis Sci. 1995 Jan;36(1):24-31
pubmed: 7822152
N Engl J Med. 1986 Aug 21;315(8):485-7
pubmed: 3736630
Clin Ophthalmol. 2019 Jul 24;13:1315-1322
pubmed: 31440021