Hydrogel-mediated co-transplantation of retinal pigmented epithelium and photoreceptors restores vision in an animal model of advanced retinal degeneration.

Animals Disease Models, Animal Epithelium Hydrogels Mice Retina Retinal Degeneration / therapy Retinal Pigment Epithelium
Blindness Co-transplantation Hydrogel Photoreceptors RPE Retinal regeneration

Journal

Biomaterials
ISSN: 1878-5905
Titre abrégé: Biomaterials
Pays: Netherlands
ID NLM: 8100316

Informations de publication

Date de publication:
10 2020
Historique:
received: 08 04 2020
revised: 07 07 2020
accepted: 10 07 2020
pubmed: 14 8 2020
medline: 15 5 2021
entrez: 14 8 2020
Statut: ppublish

Résumé

We demonstrate a novel approach to reverse advanced stages of blindness using hydrogel-mediated delivery of retinal pigmented epithelium (RPE) and photoreceptors directly to the degenerated retina of blind mice. With sodium iodate (NaIO

Identifiants

DOI: 10.1016/j.biomaterials.2020.120233 PMID: 32791386
pubmed: 32791386
pii: S0142-9612(20)30479-8
doi: 10.1016/j.biomaterials.2020.120233
pii:
doi:

Substances chimiques

Hydrogels 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

120233

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Auteurs

Nikolaos Mitrousis (N)

Institute of Biomedical Engineering, University of Toronto, Toronto, ON, M5S 3G9, Canada; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S 3E1, Canada.

Sabiha Hacibekiroglu (S)

Lunenfeld-Tanenbaum Research Institute, Mt Sinai Hospital, Toronto, ON, M5G 1X5, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, M5S 1A8, Canada.

Margaret T Ho (MT)

Institute of Biomedical Engineering, University of Toronto, Toronto, ON, M5S 3G9, Canada; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S 3E1, Canada.

Yves Sauvé (Y)

Department of Ophthalmology and Visual Sciences, University of Alberta, Edmonton, AB, T6G 2R7, Canada.

Andras Nagy (A)

Lunenfeld-Tanenbaum Research Institute, Mt Sinai Hospital, Toronto, ON, M5G 1X5, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, M5S 1A8, Canada; Department of Obstetrics and Gynaecology, University of Toronto, Toronto, ON, M5G 1E2, Canada.

Derek van der Kooy (D)

Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S 3E1, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, M5S 1A8, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada.

Molly S Shoichet (MS)

Institute of Biomedical Engineering, University of Toronto, Toronto, ON, M5S 3G9, Canada; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S 3E1, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, M5S 1A8, Canada; Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON, M5S 3E5, Canada; Department of Chemistry, University of Toronto, Toronto, ON, M5S 3H6, Canada. Electronic address: molly.shoichet@utoronto.ca.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Hydrogel-mediated co-transplantation of...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Hydrogel-mediated co-transplantation of...
questionsmedicales.fr › Tissus › Épithélium › Hydrogel-mediated co-transplantation of...
questionsmedicales.fr › Préparations pharmaceutiques › Colloïdes › Gels › Hydrogels › Hydrogel-mediated co-transplantation of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Hydrogel-mediated co-transplantation of...
questionsmedicales.fr › Organes des sens › Oeil › Rétine › Hydrogel-mediated co-transplantation of...
questionsmedicales.fr › Maladies de l'oeil › Rétinopathies › Dégénérescence de la rétine › Hydrogel-mediated co-transplantation of...
questionsmedicales.fr › Organes des sens › Oeil › Rétine › Épithélium pigmentaire de la rétine › Hydrogel-mediated co-transplantation of...