Native American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican population.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
13 08 2020
13 08 2020
Historique:
received:
14
02
2020
accepted:
30
06
2020
entrez:
15
8
2020
pubmed:
15
8
2020
medline:
12
1
2021
Statut:
epublish
Résumé
Neuromyelitis Optica (NMO) is an autoimmune disease with a higher prevalence in non-European populations. Because the Mexican population resulted from the admixture between mainly Native American and European populations, we used genome-wide microarray, HLA high-resolution typing and AQP4 gene sequencing data to analyze genetic ancestry and to seek genetic variants conferring NMO susceptibility in admixed Mexican patients. A total of 164 Mexican NMO patients and 1,208 controls were included. On average, NMO patients had a higher proportion of Native American ancestry than controls (68.1% vs 58.6%; p = 5 × 10
Identifiants
pubmed: 32792643
doi: 10.1038/s41598-020-69224-3
pii: 10.1038/s41598-020-69224-3
pmc: PMC7426416
doi:
Substances chimiques
AQP4 protein, human
0
Aquaporin 4
0
HLA Antigens
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
13706Références
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