Comparative Evaluation of Therapeutic Efficacy of Intralesional Injection of Triamcinolone Acetonide versus Intralesional Autologous Platelet-rich Plasma Injection in Alopecia Areata.
Alopecia areata
intralesional platelet-rich plasma
intralesional triamcinolone
• Intralesional steroids still remain the first-line drugs for the treatment of patchy alopecia areata.
• PRP does not have direct immunosuppressive action, despite being rich in growth factors.
Journal
Journal of cutaneous and aesthetic surgery
ISSN: 0974-2077
Titre abrégé: J Cutan Aesthet Surg
Pays: India
ID NLM: 101525405
Informations de publication
Date de publication:
Historique:
entrez:
15
8
2020
pubmed:
15
8
2020
medline:
15
8
2020
Statut:
ppublish
Résumé
Alopecia areata is a chronic non-scarring alopecia that involves scalp and/or body. Corticosteroids are the most popular drugs for its treatment. The aim of the study was to evaluate the therapeutic efficacy of intralesional injection of triamcinolone acetonide and platelet-rich plasma (PRP) in alopecia areata and to compare the efficacy of these modalities in alopecia areata. This was a randomized controlled comparative study. Forty patients were enrolled from the outpatient department and divided into two groups of 20 patients each. Group A and B randomly received intradermal triamcinolone acetonide suspension (10 mg/mL) and PRP, respectively, into the lesion using an insulin syringe in multiple 0.1 mL injections 1cm apart. The injections were repeated every 3 weeks till 12 weeks. The patients were evaluated by Severity of Alopecia Tool (SALT) score and photographically every 3 weeks till the end of 12 weeks and then at the end of 6 months. Statistical analysis used descriptive analysis along with Pearson chi-square test or Fisher exact test, paired samples, and independent samples The reduction in SALT score at each visit with respect to baseline was greater in the triamcinolone group as compared to PRP group. This signifies greater effect of triamcinolone in alopecia areata. Around 50% patients in triamcinolone group and 5% patients in PRP group showed grade V improvement. Pain during intralesional injection was higher in the PRP group. Both intralesional triamcinolone and PRP were found to be efficacious in alopecia areata but the latter produced lesser improvement.
Identifiants
pubmed: 32792771
doi: 10.4103/JCAS.JCAS_16_19
pii: JCAS-13-103
pmc: PMC7394112
doi:
Types de publication
Journal Article
Langues
eng
Pagination
103-111Informations de copyright
Copyright: © 2020 Journal of Cutaneous and Aesthetic Surgery.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
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