Factors causing oral and skin pathological features in the hyperimmunoglobulin E syndrome patient including the environmental component: a review of the literature and own experience.

HIES) dermatological manifestation environmental factor hyperimmunoglobulin E syndrome (hyper-IgE syndrome oral finding

Journal

Postepy dermatologii i alergologii
ISSN: 1642-395X
Titre abrégé: Postepy Dermatol Alergol
Pays: Poland
ID NLM: 101168357

Informations de publication

Date de publication:
Jun 2020
Historique:
received: 24 10 2018
accepted: 02 11 2018
entrez: 15 8 2020
pubmed: 15 8 2020
medline: 15 8 2020
Statut: ppublish

Résumé

The hyperimmunoglobulin E syndrome (HIES) is a rare multi-system disease with non-immunological as well as immunological abnormalities. The syndrome is characterized by a triad of the most distinctive symptoms, such as pneumonia with pneumatocele formation, recurring staphylococcal skin abscesses and a high serum concentration of IgE. Central mediators of immune responses such as STAT1 and STAT3 affect immune responses and contribute to changes of the skin microbiome which subsequently can amplify the defective immune response against microbial and fungal pathogens. Reactions related to an environmental factor, such as sun-induced skin changes, in individuals during long-term medication therapy have also been reported. The dermatological symptoms, oral status and other health problems of a hyperimmunoglobulin E syndrome paediatric patient are presented. HIES is of great importance to different professionals because sufferers require special preventive and therapeutic management from early infancy in order to avoid complications which can even prove to be life-saving for such patients.

Identifiants

pubmed: 32792871
doi: 10.5114/ada.2020.96142
pii: 96142
pmc: PMC7394163
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

326-332

Informations de copyright

Copyright: © 2020 Termedia Sp. z o. o.

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

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Auteurs

Karolina Gerreth (K)

Department of Risk Group Dentistry, Chair of Paediatric Dentistry, Poznan University of Medical Sciences, Poznan, Poland.

Aleksandra Szczawinska-Poplonyk (A)

Department of Paediatric Pneumonology, Allergology and Clinical Immunology, 3 Chair of Paediatrics, Poznan University of Medical Sciences, Poznan, Poland.

Zdzislawa Kycler (Z)

Department of Paediatric Pneumonology, Allergology and Clinical Immunology, 3 Chair of Paediatrics, Poznan University of Medical Sciences, Poznan, Poland.

Zygmunt Adamski (Z)

Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland.

Maria Borysewicz-Lewicka (M)

Chair and Department of Paediatric Dentistry, Poznan University of Medical Sciences, Poznan, Poland.

Anna Breborowicz (A)

Department of Paediatric Pneumonology, Allergology and Clinical Immunology, 3 Chair of Paediatrics, Poznan University of Medical Sciences, Poznan, Poland.

Classifications MeSH