Adaptive Potential of the Heme Oxygenase/Carbon Monoxide Pathway During Hypoxia.
altitude
carbon monoxide
cytoprotection
diving
evolution
heme oxygenase
hypoxia
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2020
2020
Historique:
received:
30
04
2020
accepted:
30
06
2020
entrez:
15
8
2020
pubmed:
15
8
2020
medline:
15
8
2020
Statut:
epublish
Résumé
Heme oxygenase (HO) enzymes catalyze heme into biliverdin, releasing carbon monoxide (CO) and iron into circulation. These byproducts of heme degradation can have potent cytoprotective effects in the face of stressors such as hypoxia and ischemia-reperfusion events. The potential for exogenous use of CO as a therapeutic agent has received increasing attention throughout the past few decades. Further, HO and CO are noted as putatively adaptive in diving mammals and certain high-altitude human populations that are frequently exposed to hypoxia and/or ischemia-reperfusion events, suggesting that HO and endogenous CO afford an evolutionary advantage for hypoxia tolerance and are critical in cell survival and injury avoidance. Our goal is to describe the importance of examining HO and CO in several systems, the physiological links, and the genetic factors that underlie variation in the HO/CO pathway. Finally, we emphasize the ways in which evolutionary perspectives may enhance our understanding of the HO/CO pathway in the context of diverse clinical settings.
Identifiants
pubmed: 32792988
doi: 10.3389/fphys.2020.00886
pmc: PMC7387684
doi:
Types de publication
Journal Article
Langues
eng
Pagination
886Subventions
Organisme : NHLBI NIH HHS
ID : T32 HL134632
Pays : United States
Organisme : NHLBI NIH HHS
ID : K24 HL132105
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL085188
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG063925
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL148436
Pays : United States
Informations de copyright
Copyright © 2020 Tift, Alves de Souza, Weber, Heinrich, Villafuerte, Malhotra, Otterbein and Simonson.
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