Alveolar Epithelial Cells Promote IGF-1 Production by Alveolar Macrophages Through TGF-β to Suppress Endogenous Inflammatory Signals.
Alveolar Epithelial Cells
/ metabolism
Animals
Apoptosis
/ immunology
Cell Communication
Disease Models, Animal
Insulin-Like Growth Factor I
/ biosynthesis
Lipopolysaccharides
/ adverse effects
Macrophage Activation
/ immunology
Macrophages, Alveolar
/ immunology
Mice
Phagocytosis
/ immunology
Phosphatidylinositol 3-Kinases
/ metabolism
Pneumonia
/ etiology
Proto-Oncogene Proteins c-akt
/ metabolism
RNA Interference
Signal Transduction
Transforming Growth Factor beta
/ metabolism
AEC
AMs
IGF-1
TGF-β
inflammation
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
01
05
2020
accepted:
15
06
2020
entrez:
15
8
2020
pubmed:
15
8
2020
medline:
21
4
2021
Statut:
epublish
Résumé
To maintain alveolar gas exchange, the alveolar surface has to limit unnecessary inflammatory responses. This involves crosstalk between alveolar epithelial cells (AECs) and alveolar macrophages (AMs) in response to damaging factors. We recently showed that insulin-like growth factor (IGF)-1 regulates the phagocytosis of AECs. AMs secrete IGF-1 into the bronchoalveolar lavage fluid (BALF) in response to inflammatory stimuli. However, whether AECs regulate the production of IGF-1 by AMs in response to inflammatory signals remains unclear, as well as the role of IGF-1 in controlling the alveolar balance in the crosstalk between AMs and AECs under inflammatory conditions. In this study, we demonstrated that IGF-1 was upregulated in BALF and lung tissues of acute lung injury (ALI) mice, and that the increased IGF-1 was mainly derived from AMs.
Identifiants
pubmed: 32793225
doi: 10.3389/fimmu.2020.01585
pmc: PMC7385185
doi:
Substances chimiques
Lipopolysaccharides
0
Transforming Growth Factor beta
0
Insulin-Like Growth Factor I
67763-96-6
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1585Informations de copyright
Copyright © 2020 Mu, Gao, Yang, He, Wu, Han, Guo, Qian and Song.
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