Mechanisms Underlying Potential Therapeutic Approaches for COVID-19.
Anti-Inflammatory Agents
/ therapeutic use
Antibodies, Viral
/ therapeutic use
Anticoagulants
/ therapeutic use
Antiviral Agents
/ therapeutic use
Betacoronavirus
/ drug effects
COVID-19
Coronavirus Infections
/ drug therapy
Cytokine Release Syndrome
/ drug therapy
Humans
Pandemics
/ prevention & control
Pneumonia, Viral
/ drug therapy
Quarantine
/ methods
Respiratory Insufficiency
/ therapy
SARS-CoV-2
COVID-19
SARS-CoV-2
cytokine treatment
immune therapy
monoclonal antibody
respiratory distress
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
24
04
2020
accepted:
08
07
2020
entrez:
15
8
2020
pubmed:
15
8
2020
medline:
25
8
2020
Statut:
epublish
Résumé
Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is a betacoronavirus, and is associated with cytokine storm inflammation and lung injury, leading to respiratory distress. The transmission of the virus is mediated by human contact. To control and prevent the spread of this virus, the majority of people worldwide are facing quarantine; patients are being subjected to non-specific treatments under isolation. To prevent and stop the COVID-19 pandemic, several clinical trials are in the pipeline. The current clinical trials either target the intracellular replication and spread of the virus or the cytokine storm inflammation seen in COVID-19 cases during the later stages of the disease. Since both targeting strategies are different, the window drug administration plays a crucial role in the efficacy of the treatment. Here, we review the mechanism underlying SARS-CoV-2 cell infection and potential future therapeutic approaches.
Identifiants
pubmed: 32793246
doi: 10.3389/fimmu.2020.01841
pmc: PMC7385230
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Antibodies, Viral
0
Anticoagulants
0
Antiviral Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1841Informations de copyright
Copyright © 2020 Benani and Ben Mkaddem.
Références
Lancet. 2020 Feb 15;395(10223):514-523
pubmed: 31986261
Pharmaceut Med. 2020 Aug;34(4):223-231
pubmed: 32535732
Emerg Infect Dis. 2005 Mar;11(3):417-24
pubmed: 15757557
Eur J Pharmacol. 2009 Dec 25;625(1-3):220-33
pubmed: 19836374
Lancet. 2020 Feb 15;395(10223):473-475
pubmed: 32043983
Viral Immunol. 2019 Jul/Aug;32(6):244-251
pubmed: 31188076
Int J Antimicrob Agents. 2020 Jul;56(1):105949
pubmed: 32205204
Lancet. 2004 Jun 26;363(9427):2139-41
pubmed: 15220038
Annu Rev Med. 2017 Jan 14;68:387-399
pubmed: 27576010
JAMA. 2003 Jun 4;289(21):2801-9
pubmed: 12734147
Nat Immunol. 2006 Mar;7(3):311-7
pubmed: 16462739
J Virol. 2006 Jan;80(2):941-50
pubmed: 16378996
Thromb Haemost. 2020 Jun;120(6):998-1000
pubmed: 32316063
Clin Immunol. 2014 Dec;155(2):213-9
pubmed: 25451159
MAbs. 2010 Jan-Feb;2(1):53-66
pubmed: 20168090
J Am Acad Dermatol. 1988 Jun;18(6):1246-52
pubmed: 3385039
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2020 May 25;49(2):215-219
pubmed: 32391667
Science. 2003 Oct 10;302(5643):276-8
pubmed: 12958366
Autophagy. 2013 Jul;9(7):1119-20
pubmed: 23670050
Cell Res. 2020 Mar;30(3):269-271
pubmed: 32020029
Eur J Clin Microbiol Infect Dis. 2020 Jul;39(7):1209-1220
pubmed: 32328850
Clin Infect Dis. 2020 Jul 28;71(15):732-739
pubmed: 32150618
Cell Mol Life Sci. 2007 Aug;64(15):2006-12
pubmed: 17558469
Sci Transl Med. 2017 Jun 28;9(396):
pubmed: 28659436
Asian Pac J Allergy Immunol. 2020 Mar;38(1):10-18
pubmed: 32134278
Methods Enzymol. 1995;248:283-305
pubmed: 7674927
J Virol. 2005 Feb;79(3):1635-44
pubmed: 15650189
Adv Exp Med Biol. 1980;130:1-27
pubmed: 6250339
Clin Infect Dis. 2020 Apr 27;:
pubmed: 32338708
Curr Pharmacol Rep. 2020 May 11;:1-15
pubmed: 32395418
Lancet. 2020 May 2;395(10234):1407-1409
pubmed: 32278362
Crit Care Med. 2020 May 27;:
pubmed: 32467443
Parasitol Res. 2012 Jul;111(1):1-6
pubmed: 22411634
J Cardiovasc Pharmacol. 2002 Apr;39(4):478-87
pubmed: 11904521
J Immunol. 2011 Apr 15;186(8):4794-804
pubmed: 21398612
Immunotherapy. 2016 Jul;8(8):959-70
pubmed: 27381687
Clinics (Sao Paulo). 2013 Jun;68(6):766-71
pubmed: 23778483
J Korean Med Sci. 2020 Feb 17;35(6):e79
pubmed: 32056407
Platelets. 2020 May 18;31(4):490-496
pubmed: 32297540
J Virol. 2020 Mar 17;94(7):
pubmed: 31996437
PLoS Med. 2006 Jul;3(7):e237
pubmed: 16796401
J Pharm Biomed Anal. 2017 Oct 25;145:248-254
pubmed: 28668653
Ann Oncol. 2020 Jul;31(7):961-964
pubmed: 32247642
Cell. 2010 Feb 5;140(3):313-26
pubmed: 20144757
JAMA Ophthalmol. 2014 Dec;132(12):1453-60
pubmed: 25275721
Nat Rev Drug Discov. 2020 Mar;19(3):149-150
pubmed: 32127666
mBio. 2018 Mar 6;9(2):
pubmed: 29511076
J Natl Cancer Inst. 1983 Nov;71(5):1053-7
pubmed: 6580482
Antimicrob Agents Chemother. 2016 Oct 21;60(11):6532-6539
pubmed: 27550352
J Virol. 2009 Apr;83(8):3528-39
pubmed: 19193795
J Virol. 2010 Dec;84(24):12658-64
pubmed: 20926566
J Gastroenterol. 2010 Mar;45(3):335-41
pubmed: 19876587
J Clin Invest. 2020 May 1;130(5):2202-2205
pubmed: 32217834
J Biol Regul Homeost Agents. 2020 Mar 14;34(2):327-331
pubmed: 32171193
PLoS One. 2014 Jul 14;9(7):e102415
pubmed: 25019613
BMC Musculoskelet Disord. 2019 Jun 15;20(1):286
pubmed: 31200688
Med Mal Infect. 2020 Jun;50(4):384
pubmed: 32240719
Trials. 2020 May 24;21(1):422
pubmed: 32448345
Virol J. 2005 Aug 22;2:69
pubmed: 16115318
Nature. 2016 Mar 17;531(7594):381-5
pubmed: 26934220
Jpn J Pharmacol. 1986 Jun;41(2):155-62
pubmed: 2427760
J Virol. 2011 Jan;85(2):873-82
pubmed: 21068237
Biochem Biophys Res Commun. 2005 Jan 28;326(4):905-8
pubmed: 15607755
Drug Saf. 2020 Jul;43(7):645-656
pubmed: 32468196
J Rheumatol. 1997 Jan;24(1):55-60
pubmed: 9002011
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
Science. 2005 Sep 16;309(5742):1864-8
pubmed: 16166518
Front Immunol. 2020 May 01;11:827
pubmed: 32425950
Internist (Berl). 2019 Nov;60(11):1136-1145
pubmed: 31455974
Front Microbiol. 2019 May 10;10:1057
pubmed: 31134045
J Virol. 2005 May;79(10):5900-6
pubmed: 15857975
J Int Med Res. 2018 Jun;46(6):2410-2422
pubmed: 29644918
J Virol. 2016 Jan 06;90(6):3086-92
pubmed: 26739045
Sci Transl Med. 2019 Jul 10;11(500):
pubmed: 31292264
Lancet. 2020 Feb 15;395(10223):507-513
pubmed: 32007143
Cell. 2020 Apr 16;181(2):271-280.e8
pubmed: 32142651
J Med Virol. 2020 Apr 8;:
pubmed: 32266995
Int J Antimicrob Agents. 2020 Apr;55(4):105933
pubmed: 32147516
Blood Rev. 2020 May 15;:100707
pubmed: 32425294
Lancet Infect Dis. 2006 Feb;6(2):67-9
pubmed: 16439323
J Clin Virol. 2004 Sep;31(1):69-75
pubmed: 15288617