Proof-of-Concept of Electrical Activation of Liposome Nanocarriers: From Dry to Wet Experiments.
controlled release
electropermeabilization
electroporation
exposure systems
liposome vesicles
multiphysics modeling
nanosecond pulsed electric fields
Journal
Frontiers in bioengineering and biotechnology
ISSN: 2296-4185
Titre abrégé: Front Bioeng Biotechnol
Pays: Switzerland
ID NLM: 101632513
Informations de publication
Date de publication:
2020
2020
Historique:
received:
15
04
2020
accepted:
26
06
2020
entrez:
15
8
2020
pubmed:
15
8
2020
medline:
15
8
2020
Statut:
epublish
Résumé
The increasing interest toward biocompatible nanotechnologies in medicine, combined with electric fields stimulation, is leading to the development of electro-sensitive smart systems for drug delivery applications. To this regard, recently the use of pulsed electric fields to trigger release across phospholipid membranes of liposomes has been numerically studied, for a deeper understanding of the phenomena at the molecular scale. Aim of this work is to give an experimental validation of the feasibility to control the release from liposome vesicles, using nanosecond pulsed electric fields characterized by a 10 ns duration and intensity in the order of MV/m. The results are supported by multiphysics simulations which consider the coupling of three physics (electromagnetics, thermal and pore kinetics) in order to explain the occurring physical interactions at the microscopic level and provide useful information on the characteristics of the train of pulses needed to obtain quantitative results in terms of liposome electropermeabilization. Finally, a complete characterization of the exposure system is also provided to support the reliability and validity of the study.
Identifiants
pubmed: 32793572
doi: 10.3389/fbioe.2020.00819
pmc: PMC7390969
doi:
Types de publication
Journal Article
Langues
eng
Pagination
819Informations de copyright
Copyright © 2020 Caramazza, Nardoni, De Angelis, Paolicelli, Liberti, Apollonio and Petralito.
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