Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers.

Animals Biomarkers, Tumor / blood Cell Line Extracellular Vesicles / metabolism HSC70 Heat-Shock Proteins / metabolism Humans Machine Learning Mice Mice, Inbred C57BL Microfilament Proteins / metabolism Neoplasms / diagnosis Proteome / analysis Proteomics / methods Sensitivity and Specificity Tetraspanin 29 / metabolism rap GTP-Binding Proteins / metabolism
biomarkers cancer cancer of unknown primary origin damage-associated molecular patterns early cancer detection exomeres exosomes extracellular vesicles and particles liquid biopsy proteomics

Journal

Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066

Informations de publication

Date de publication:
20 08 2020
Historique:
received: 06 01 2020
revised: 23 04 2020
accepted: 09 07 2020
pubmed: 17 8 2020
medline: 2 4 2021
entrez: 16 8 2020
Statut: ppublish

Résumé

There is an unmet clinical need for improved tissue and liquid biopsy tools for cancer detection. We investigated the proteomic profile of extracellular vesicles and particles (EVPs) in 426 human samples from tissue explants (TEs), plasma, and other bodily fluids. Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers. To confirm that EVPs are ideal diagnostic tools, we analyzed proteomes of TE- (n = 151) and plasma-derived (n = 120) EVPs. Comparison of TE EVPs identified proteins (e.g., VCAN, TNC, and THBS2) that distinguish tumors from normal tissues with 90% sensitivity/94% specificity. Machine-learning classification of plasma-derived EVP cargo, including immunoglobulins, revealed 95% sensitivity/90% specificity in detecting cancer. Finally, we defined a panel of tumor-type-specific EVP proteins in TEs and plasma, which can classify tumors of unknown primary origin. Thus, EVP proteins can serve as reliable biomarkers for cancer detection and determining cancer type.

Identifiants

DOI: 10.1016/j.cell.2020.07.009 PMID: 32795414 PMC: PMC7522766
pubmed: 32795414
pii: S0092-8674(20)30874-6
doi: 10.1016/j.cell.2020.07.009
pmc: PMC7522766
mid: NIHMS1612511
pii:
doi:

Substances chimiques

Biomarkers, Tumor 0
HSC70 Heat-Shock Proteins 0
HSPA8 protein, human 0
Microfilament Proteins 0
Proteome 0
Tetraspanin 29 0
moesin 144131-77-1
RAP1B protein, human EC 3.6.1.-
rap GTP-Binding Proteins EC 3.6.5.2

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

1044-1061.e18

Subventions

Organisme : NCI NIH HHS
ID : U54 CA163120
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA163117
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA218513
Pays : United States
Organisme : NIOSH CDC HHS
ID : U19 OH009077
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI144301
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002384
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA210240
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA064786
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA207983
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA127297
Pays : United States
Organisme : NCI NIH HHS
ID : R50 CA211462
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR027699
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA169416
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA169538
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA224175
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA217169
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA232093
Pays : United States

Commentaires et corrections

Type : CommentIn
Type : CommentIn
Type : CommentIn

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Interests D.L., A.H., H.S.K., and L.B. have filed a U.S. patent application related to this work.

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Auteurs

Ayuko Hoshino (A)

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; School of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan; Japan Science and Technology Agency, PRESTO, Tokyo, Japan. Electronic address: ayukohoshino@bio.titech.ac.jp.

Han Sang Kim (HS)

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Yonsei Cancer Center, Division of Medical Oncology, Department of Internal Medicine, Brain Korea 21 Plus Project for Medical Sciences, Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Korea.

Linda Bojmar (L)

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden; Department of Immunology, Genetics and Pathology, Uppsala University, Rudbeck Laboratory, Uppsala, Sweden.

Kofi Ennu Gyan (KE)

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Tri-Institutional PhD Program in Computational Biology and Medicine, New York, NY, USA.

Michele Cioffi (M)

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.

Jonathan Hernandez (J)

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Surgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, MD USA.

Constantinos P Zambirinis (CP)

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Gonçalo Rodrigues (G)

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Graduate Program in Areas of Basic and Applied Biology, Abel Salazar Biomedical Sciences Institute, University of Porto, Porto, Portugal.

Henrik Molina (H)

Proteomics Resource Center, The Rockefeller University, New York, NY, USA.

Søren Heissel (S)

Proteomics Resource Center, The Rockefeller University, New York, NY, USA.

Milica Tesic Mark (MT)

Proteomics Resource Center, The Rockefeller University, New York, NY, USA.

Loïc Steiner (L)

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Swiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland.

Alberto Benito-Martin (A)

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.

Serena Lucotti (S)

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.

Angela Di Giannatale (A)

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Department of Pediatric Haematology/Oncology, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.

Katharine Offer (K)

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.

Miho Nakajima (M)

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.

Caitlin Williams (C)

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.

Laura Nogués (L)

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Microenvironment and Metastasis Laboratory, Department of Molecular Oncology, Spanish National Cancer Research Center (CNIO), Madrid, Spain.

Fanny A Pelissier Vatter (FA)

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.

Ayako Hashimoto (A)

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; School of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan; Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan.

Alexander E Davies (AE)

Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA.

Daniela Freitas (D)

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; i3S-Institute for Research and Innovation in Health, University of Porto, Rua Alfredo Allen 208, Porto, Portugal.

Candia M Kenific (CM)

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.

Yonathan Ararso (Y)

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.

Weston Buehring (W)

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.

Pernille Lauritzen (P)

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.

Yusuke Ogitani (Y)

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.

Kei Sugiura (K)

School of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan; Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.

Naoko Takahashi (N)

School of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan.

Maša Alečković (M)

Department of Molecular Biology, Princeton University, Princeton, NJ, USA.

Kayleen A Bailey (KA)

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.

Joshua S Jolissant (JS)

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Huajuan Wang (H)

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.

Ashton Harris (A)

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.

L Miles Schaeffer (LM)

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.

Guillermo García-Santos (G)

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Department of General and Gastrointestinal Surgery, Hospital Universitario Central de Asturias (HUCA), Oviedo, Spain.

Zoe Posner (Z)

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.

Vinod P Balachandran (VP)

Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Yasmin Khakoo (Y)

Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

G Praveen Raju (GP)

Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Avigdor Scherz (A)

Department of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel.

Irit Sagi (I)

Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel.

Ruth Scherz-Shouval (R)

Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.

Yosef Yarden (Y)

Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel.

Moshe Oren (M)

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

Mahathi Malladi (M)

Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Mary Petriccione (M)

Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Kevin C De Braganca (KC)

Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Maria Donzelli (M)

Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Cheryl Fischer (C)

Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Stephanie Vitolano (S)

Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Geraldine P Wright (GP)

Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Lee Ganshaw (L)

Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Mariel Marrano (M)

Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Amina Ahmed (A)

Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Joe DeStefano (J)

Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Enrico Danzer (E)

Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Pediatric Surgical Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Michael H A Roehrl (MHA)

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Norman J Lacayo (NJ)

Lucile Packard Children's Hospital Stanford, Stanford, CA, USA.

Theresa C Vincent (TC)

Department of Immunology, Genetics and Pathology, Uppsala University, Rudbeck Laboratory, Uppsala, Sweden; Department of Microbiology, New York University School of Medicine, New York, NY, USA.

Martin R Weiser (MR)

Colorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Mary S Brady (MS)

Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Paul A Meyers (PA)

Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Leonard H Wexler (LH)

Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Srikanth R Ambati (SR)

Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Alexander J Chou (AJ)

Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Emily K Slotkin (EK)

Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Shakeel Modak (S)

Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Stephen S Roberts (SS)

Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Ellen M Basu (EM)

Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Daniel Diolaiti (D)

Perlmutter Cancer Center, New York University Langone Health, New York, NY, USA.

Benjamin A Krantz (BA)

Perlmutter Cancer Center, New York University Langone Health, New York, NY, USA; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Fatima Cardoso (F)

Breast Unit, Champalimaud Clinical Center/Champalimaud Foundation, Lisbon, Portugal.

Amber L Simpson (AL)

Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Michael Berger (M)

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Charles M Rudin (CM)

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Diane M Simeone (DM)

Perlmutter Cancer Center, New York University Langone Health, New York, NY, USA.

Maneesh Jain (M)

Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.

Cyrus M Ghajar (CM)

Public Health Sciences Division/Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Surinder K Batra (SK)

Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.

Ben Z Stanger (BZ)

Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Jack Bui (J)

Department of Pathology, University of California San Diego, La Jolla, CA, USA.

Kristy A Brown (KA)

Department of Medicine, Weill Cornell Medicine, New York, NY, USA.

Vinagolu K Rajasekhar (VK)

Orthopedic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

John H Healey (JH)

Orthopedic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Maria de Sousa (M)

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Graduate Program in Areas of Basic and Applied Biology, Abel Salazar Biomedical Sciences Institute, University of Porto, Porto, Portugal.

Kim Kramer (K)

Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Sujit Sheth (S)

Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.

Jeanine Baisch (J)

Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA; Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY, USA.

Virginia Pascual (V)

Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA; Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY, USA.

Todd E Heaton (TE)

Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Pediatric Surgical Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Michael P La Quaglia (MP)

Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Pediatric Surgical Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

David J Pisapia (DJ)

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.

Robert Schwartz (R)

Division of Gastroenterology & Hepatology, Weill Cornell Medicine, New York, NY, USA.

Haiying Zhang (H)

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.

Yuan Liu (Y)

Thoracic Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Arti Shukla (A)

Department of Pathology and Laboratory Medicine, University of Vermont, Burlington, VT, USA.

Laurence Blavier (L)

Department of Pediatrics and Biochemistry and Molecular Medicine, University of Southern California, CA, USA.

Yves A DeClerck (YA)

Department of Pediatrics and Biochemistry and Molecular Medicine, University of Southern California, CA, USA.

Mark LaBarge (M)

Department of Population Sciences, Beckman Research Institute at City of Hope, Duarte, CA, USA.

Mina J Bissell (MJ)

Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.

Thomas C Caffrey (TC)

Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.

Paul M Grandgenett (PM)

Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.

Michael A Hollingsworth (MA)

Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.

Jacqueline Bromberg (J)

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Medicine, Weill Cornell Medicine, New York, NY, USA.

Bruno Costa-Silva (B)

Champalimaud Research, Champalimaud Foundation, Lisbon, Portugal.

Hector Peinado (H)

Microenvironment and Metastasis Laboratory, Department of Molecular Oncology, Spanish National Cancer Research Center (CNIO), Madrid, Spain.

Yibin Kang (Y)

Department of Molecular Biology, Princeton University, Princeton, NJ, USA.

Benjamin A Garcia (BA)

Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Eileen M O'Reilly (EM)

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

David Kelsen (D)

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Tanya M Trippett (TM)

Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

David R Jones (DR)

Thoracic Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Irina R Matei (IR)

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.

William R Jarnagin (WR)

Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address: jarnagiw@mskcc.org.

David Lyden (D)

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA. Electronic address: dcl2001@med.cornell.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Extracellular Vesicle and Particle Biomarkers...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Extracellular Vesicle and Particle Biomarkers...
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questionsmedicales.fr › Cellules › Structures cellulaires › Espace extracellulaire › Vésicules extracellulaires › Extracellular Vesicle and Particle Biomarkers...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Chaperons moléculaires › Protéines du choc thermique › Protéines du choc thermique HSP70 › Protéines du choc thermique HSC70 › Extracellular Vesicle and Particle Biomarkers...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Extracellular Vesicle and Particle Biomarkers...
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questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Extracellular Vesicle and Particle Biomarkers...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Extracellular Vesicle and Particle Biomarkers...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Protéines des microfilaments › Extracellular Vesicle and Particle Biomarkers...
questionsmedicales.fr › Tumeurs › Extracellular Vesicle and Particle Biomarkers...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéome › Extracellular Vesicle and Particle Biomarkers...
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questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Tétraspanines › Antigène CD9 › Extracellular Vesicle and Particle Biomarkers...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines G › Protéines G monomériques › Protéines G rap › Extracellular Vesicle and Particle Biomarkers...