Intensity- and timing-dependent modulation of motion perception with transcranial magnetic stimulation of visual cortex.
Motion sensitive cortex
TMS
TMS Evoked potential
Transcranial magnetic stimulation
Visual evoked potential
Visual motion
Journal
Neuropsychologia
ISSN: 1873-3514
Titre abrégé: Neuropsychologia
Pays: England
ID NLM: 0020713
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
03
06
2020
revised:
23
07
2020
accepted:
04
08
2020
pubmed:
17
8
2020
medline:
25
6
2021
entrez:
16
8
2020
Statut:
ppublish
Résumé
Despite the widespread use of transcranial magnetic stimulation (TMS) in research and clinical care, the dose-response relations and neurophysiological correlates of modulatory effects remain relatively unexplored. To fill this gap, we studied modulation of visual processing as a function of TMS parameters. Our approach combined electroencephalography (EEG) with application of single pulse TMS to visual cortex as participants performed a motion perception task. During each participants' first visit, motion coherence thresholds, 64-channel visual evoked potentials (VEPs), and TMS resting motor thresholds (RMT) were measured. In second and third visits, single pulse TMS was delivered at one of two latencies, either 30 ms before the onset of motion or at the onset latency of the N2 VEP component derived from the first session. TMS was delivered at 0%, 80%, 100%, or 120% of RMT over the site of N2 peak activity, or at 120% over vertex. Behavioral results demonstrated a significant main effect of TMS timing on accuracy, with better performance when TMS was applied at the N2-Onset timing versus Pre-Onset, as well as a significant interaction, indicating that 80% intensity produced higher accuracy than other conditions at the N2-Onset. TMS effects on the P3 VEP showed reduced amplitudes in the 80% Pre-Onset condition, an increase for the 120% N2-Onset condition, and monotonic amplitude scaling with stimulation intensity. The N2 component was not affected by TMS. These findings reveal the influence of TMS intensity and timing on visual perception and electrophysiological responses, with optimal facilitation at stimulation intensities below RMT.
Identifiants
pubmed: 32795456
pii: S0028-3932(20)30254-2
doi: 10.1016/j.neuropsychologia.2020.107581
pmc: PMC7554219
mid: NIHMS1622789
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
107581Subventions
Organisme : NIMH NIH HHS
ID : RF1 MH114253
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
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