Pharmacological management of COVID-19 patients with ARDS (CARDS): A narrative review.
ARDS
CARDS
COVID-19
Pharmacological therapy
Journal
Respiratory medicine
ISSN: 1532-3064
Titre abrégé: Respir Med
Pays: England
ID NLM: 8908438
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
15
05
2020
revised:
30
07
2020
accepted:
01
08
2020
pubmed:
17
8
2020
medline:
25
9
2020
entrez:
16
8
2020
Statut:
ppublish
Résumé
Coronavirus disease 2019 (COVID-19) is highly infectious. It has been highlighted that if not expertly and individually managed with consideration of the vasocentric features, a COVID-19 patient with an acute respiratory distress syndrome (CARDS) may eventually develop multiorgan failure. Unfortunately, there is still no definite drug for CARDS that is capable of reducing either short-term or long-term mortality and no specific treatments for COVID-19 exist right now. In this narrative review, based on a selective literature search in EMBASE, MEDLINE, Scopus, The Cochrane Library, Web of Science, and Google Scholar and ClinicalTrials.gov, we have examined the emerging evidence on the possible treatment of CARDS. Although numerous pharmacologic therapies to improve clinical outcomes in CARDS have been studied also in clinical trials, none have shown efficacy and there is great uncertainty about their effectiveness. There is still no recommendation for the therapeutic use of any specific agent to treat CARDS because no drugs are validated to have significant efficacy in clinical treatment of COVID-19 patients in large-scale trials. However, there exist a number of drugs that may be useful at least in some patients. The real challenge now is to link the right patient to the right treatment.
Identifiants
pubmed: 32795902
pii: S0954-6111(20)30254-7
doi: 10.1016/j.rmed.2020.106114
pmc: PMC7402220
pii:
doi:
Substances chimiques
Antiviral Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
106114Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
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