Potential Mechanisms of Bisphenol A (BPA) Contributing to Human Disease.
bisphenol A
cancer
epigenetics
metabolism
receptors
transcription factors
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
11 Aug 2020
11 Aug 2020
Historique:
received:
06
07
2020
revised:
06
08
2020
accepted:
07
08
2020
entrez:
16
8
2020
pubmed:
17
8
2020
medline:
18
2
2021
Statut:
epublish
Résumé
Bisphenol A (BPA) is an organic synthetic compound serving as a monomer to produce polycarbonate plastic, widely used in the packaging for food and drinks, medical devices, thermal paper, and dental materials. BPA can contaminate food, beverage, air, and soil. It accumulates in several human tissues and organs and is potentially harmful to human health through different molecular mechanisms. Due to its hormone-like properties, BPA may bind to estrogen receptors, thereby affecting both body weight and tumorigenesis. BPA may also affect metabolism and cancer progression, by interacting with GPR30, and may impair male reproductive function, by binding to androgen receptors. Several transcription factors, including PPARγ, C/EBP, Nrf2, HOX, and HAND2, are involved in BPA action on fat and liver homeostasis, the cardiovascular system, and cancer. Finally, epigenetic changes, such as DNA methylation, histones modification, and changes in microRNAs expression contribute to BPA pathological effects. This review aims to provide an extensive and comprehensive analysis of the most recent evidence about the potential mechanisms by which BPA affects human health.
Identifiants
pubmed: 32796699
pii: ijms21165761
doi: 10.3390/ijms21165761
pmc: PMC7460848
pii:
doi:
Substances chimiques
Benzhydryl Compounds
0
Phenols
0
Receptors, Cell Surface
0
Transcription Factors
0
bisphenol A
MLT3645I99
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : IG-19001
Organisme : Regione Campania
ID : POR Campania FESR "Coepica"
Références
Toxicology. 2019 Feb 1;413:48-55
pubmed: 30582956
Development. 2005 Jan;132(1):189-201
pubmed: 15576406
Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Sep;1862(9):869-882
pubmed: 28483554
Reprod Toxicol. 2013 Dec;42:256-68
pubmed: 23892310
Semin Fetal Neonatal Med. 2014 Jun;19(3):195-202
pubmed: 24388781
Biochem Biophys Res Commun. 1997 Nov 26;240(3):737-41
pubmed: 9398636
Development. 2014 Aug;141(16):3112-22
pubmed: 25038045
Biochim Biophys Acta. 2015 Jun;1849(6):697-708
pubmed: 25725483
Int J Mol Sci. 2012;13(8):10143-53
pubmed: 22949852
Cardiovasc Res. 2011 Jul 15;91(2):279-88
pubmed: 21602174
Cancer Biol Ther. 2012 Mar;13(5):296-306
pubmed: 22258036
J Expo Sci Environ Epidemiol. 2015 Nov-Dec;25(6):544-56
pubmed: 26350983
FASEB J. 2007 Jan;21(1):239-46
pubmed: 17093138
ACS Chem Biol. 2007 Aug 17;2(8):536-44
pubmed: 17655271
Endocrinology. 2013 May;154(5):1873-84
pubmed: 23525218
J Mol Biol. 2014 Oct 9;426(20):3426-41
pubmed: 25088689
Mol Cell Endocrinol. 2009 May 25;304(1-2):49-54
pubmed: 19433247
Front Endocrinol (Lausanne). 2020 Jun 12;11:353
pubmed: 32595601
J Endocrinol. 2015 Jul;226(1):35-42
pubmed: 25972359
Int J Environ Res Public Health. 2020 Apr 13;17(8):
pubmed: 32294918
Environ Sci Technol. 2017 Nov 7;51(21):12796-12805
pubmed: 29016128
PLoS One. 2015 Mar 23;10(3):e0120330
pubmed: 25799048
Endocrinology. 2014 Mar;155(3):805-17
pubmed: 24424067
Int J Environ Res Public Health. 2015 Sep 07;12(9):11101-16
pubmed: 26371021
Toxicol In Vitro. 2019 Dec;61:104621
pubmed: 31415812
Endocr Rev. 2009 Feb;30(1):75-95
pubmed: 19074586
Sci Total Environ. 2016 Dec 1;572:770-781
pubmed: 27586167
Int J Hyg Environ Health. 2003 Jun;206(3):223-9
pubmed: 12872532
J Appl Physiol (1985). 2001 Oct;91(4):1860-7
pubmed: 11568173
FASEB J. 2010 Jul;24(7):2273-80
pubmed: 20181937
Environ Health Perspect. 2017 Jul 11;125(7):077007
pubmed: 28728135
Gene. 2016 Sep 30;590(2):234-43
pubmed: 27182052
Biochem Pharmacol. 1994 Jan 13;47(1):137-43
pubmed: 7906121
Int Arch Occup Environ Health. 2016 Aug;89(6):935-46
pubmed: 27126703
Rev Environ Contam Toxicol. 2014;228:57-82
pubmed: 24162092
Environ Health Perspect. 2017 Aug 04;125(8):087005
pubmed: 28796629
Anal Bioanal Chem. 2010 Sep;398(1):571-6
pubmed: 20623271
Endocrinology. 2016 May;157(5):1764-74
pubmed: 27022677
Biomedicines. 2020 May 28;8(6):
pubmed: 32481506
Toxicol Res (Camb). 2016 Jun 20;5(5):1400-1409
pubmed: 30090444
Toxicol Appl Pharmacol. 2015 Apr 15;284(2):101-12
pubmed: 25748669
Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11603-8
pubmed: 11027358
Toxicol Appl Pharmacol. 2013 Oct 1;272(1):127-36
pubmed: 23714657
J Recept Signal Transduct Res. 2011 Feb;31(1):20-5
pubmed: 21175265
FASEB J. 2017 Dec;31(12):5184-5195
pubmed: 28774890
Toxicol In Vitro. 2009 Aug;23(5):950-4
pubmed: 19457453
PLoS One. 2016 Sep 29;11(9):e0163318
pubmed: 27685785
Cancer Res. 2006 Jun 1;66(11):5624-32
pubmed: 16740699
Bull Environ Contam Toxicol. 2016 Jul;97(1):4-10
pubmed: 27169527
Reprod Toxicol. 2007 Aug-Sep;24(2):139-77
pubmed: 17825522
Sci Rep. 2016 Aug 09;6:31331
pubmed: 27502578
Environ Mol Mutagen. 2012 Jun;53(5):334-42
pubmed: 22467340
PLoS One. 2014 Jun 24;9(6):e100214
pubmed: 24959901
Ulster Med J. 2006 Jan;75(1):23-31
pubmed: 16457401
Toxicol Appl Pharmacol. 2010 Oct 15;248(2):111-21
pubmed: 20678512
Cancers (Basel). 2019 Sep 12;11(9):
pubmed: 31547326
Semin Cancer Biol. 1998 Aug;8(4):237-44
pubmed: 9870030
PLoS One. 2012;7(3):e32754
pubmed: 22403704
Toxicol Lett. 2013 Dec 16;223(3):295-305
pubmed: 24177261
Sci Rep. 2016 Oct 04;6:34302
pubmed: 27698362
Clin Cancer Res. 2006 Nov 1;12(21):6359-66
pubmed: 17085646
Reprod Toxicol. 2011 Jan;31(1):1-9
pubmed: 20887781
Gene. 2018 Mar 20;647:235-243
pubmed: 29317319
Int J Environ Res Public Health. 2014 Jul 22;11(7):7537-61
pubmed: 25054232
Curr Hypertens Rep. 2020 Feb 29;22(3):23
pubmed: 32114652
Environ Health Perspect. 2005 Aug;113(8):926-33
pubmed: 16079060
Annu Rev Pharmacol Toxicol. 2013;53:401-26
pubmed: 23294312
Genomics. 1993 Jul;17(1):263-5
pubmed: 8406468
Mol Interv. 2002 Jul;2(4):219-28
pubmed: 14993393
Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):541-6
pubmed: 9892669
N Engl J Med. 2009 Nov 19;361(21):2066-78
pubmed: 19923578
Biochem Biophys Res Commun. 1996 Nov 12;228(2):285-92
pubmed: 8920907
Dose Response. 2015 Jul 29;13(3):1559325815598308
pubmed: 26674671
Genes Environ. 2020 Mar 11;42:13
pubmed: 32175033
Proc Natl Acad Sci U S A. 2010 Jan 19;107(3):1100-5
pubmed: 20080567
J Endocrinol. 1998 Sep;158(3):327-39
pubmed: 9846162
Horm Cancer. 2010 Jun;1(3):146-55
pubmed: 21761357
Int J Environ Res Public Health. 2016 Oct 06;13(10):
pubmed: 27782064
Dose Response. 2015 Oct 07;13(4):1559325815610582
pubmed: 26740804
Hum Reprod. 2010 Feb;25(2):519-27
pubmed: 19906654
Physiol Res. 2015;64(Suppl 2):S303-11
pubmed: 26680493
Trends Endocrinol Metab. 2001 May-Jun;12(4):152-6
pubmed: 11295570
Environ Sci Technol. 2010 Feb 15;44(4):1458-63
pubmed: 20030380
Cancer Res. 2005 Oct 1;65(19):8640-5
pubmed: 16204031
J Biol Chem. 2003 Jan 24;278(4):2701-12
pubmed: 12421825
Fertil Steril. 2016 Sep 15;106(4):827-56
pubmed: 27417731
J Clin Endocrinol Metab. 1997 Dec;82(12):4258-65
pubmed: 9398750
Phytother Res. 2014 Oct;28(10):1553-60
pubmed: 24831732
Chem Res Toxicol. 2003 Oct;16(10):1338-58
pubmed: 14565775
Environ Pollut. 2019 Mar;246:1008-1019
pubmed: 31126002
Environ Health Perspect. 2009 Oct;117(10):1549-55
pubmed: 20019905
Endocrinology. 1997 Mar;138(3):863-70
pubmed: 9048584
Reprod Toxicol. 2007 Apr-May;23(3):383-90
pubmed: 17123778
Toxicol Appl Pharmacol. 2016 Apr 15;297:32-40
pubmed: 26944108
Int J Cancer. 2012 Jan 1;130(1):241-2
pubmed: 21312194
Basic Clin Pharmacol Toxicol. 2016 Oct;119(4):389-95
pubmed: 27038254
Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13056-61
pubmed: 17670942
Reprod Toxicol. 2013 Jun;37:15-23
pubmed: 23348055
BMC Genomics. 2014 Jan 17;15:30
pubmed: 24433282
Endocrinology. 2017 Nov 1;158(11):3844-3858
pubmed: 28938450
Oncotarget. 2017 Jul 25;8(30):49005-49015
pubmed: 28446726
J Endocrinol Invest. 2016 Mar;39(3):259-63
pubmed: 26105974
Carcinogenesis. 2013 Mar;34(3):703-12
pubmed: 23222814
PLoS One. 2014 Jul 02;9(7):e99800
pubmed: 24988533
Nat Rev Genet. 2001 Jan;2(1):39-48
pubmed: 11253067
J Cell Biochem. 2016 Feb;117(2):344-50
pubmed: 26146954
Anticancer Res. 2000 Sep-Oct;20(5A):3281-6
pubmed: 11062754
Gynecol Oncol. 2009 Sep;114(3):465-71
pubmed: 19501895
Adipocyte. 2014 Jul 1;3(3):170-9
pubmed: 25068083
Environ Health Perspect. 2005 Aug;113(8):969-77
pubmed: 16079065
Prog Lipid Res. 2014 Jan;53:124-44
pubmed: 24362249
Toxicol In Vitro. 2013 Sep;27(6):1634-43
pubmed: 23603478
Reprod Toxicol. 2010 Jul;29(4):401-6
pubmed: 20417706
Steroids. 2002 May;67(6):471-5
pubmed: 11960623
Environ Health Perspect. 2007 Jan;115(1):80-6
pubmed: 17366824
Drug Metab Pharmacokinet. 2018 Aug;33(4):194-202
pubmed: 29960846
Endocrinology. 1998 Oct;139(10):4252-63
pubmed: 9751507
Curr Genomics. 2019 May;20(4):260-274
pubmed: 32030086
Toxicol In Vitro. 2015 Dec 25;30(1 Pt B):521-8
pubmed: 26363202
Fertil Steril. 2015 Jan;103(1):11-21
pubmed: 25475787
Epigenetics. 2016 Sep;11(9):674-689
pubmed: 27415467
Environ Sci Technol. 2012 Jun 19;46(12):6515-22
pubmed: 22591511
Toxicol Lett. 2006 Dec 1;167(2):95-105
pubmed: 17049190
Chemosphere. 2012 Nov;89(8):988-94
pubmed: 22840535
Kidney Int. 2014 Feb;85(2):333-343
pubmed: 24025640
Reprod Toxicol. 2007 Aug-Sep;24(2):178-98
pubmed: 17628395
Diabetes Metab J. 2019 Feb;43(1):46-48
pubmed: 30793551
Clin Epigenetics. 2018 Apr 20;10:58
pubmed: 29721103
Toxicol Lett. 2015 Jan 5;232(1):293-300
pubmed: 25455458
Birth Defects Res B Dev Reprod Toxicol. 2008 Jun;83(3):157-395
pubmed: 18613034
Environ Pollut. 2019 Dec;255(Pt 2):113318
pubmed: 31610501
Mol Cell Endocrinol. 2009 Sep 24;308(1-2):32-8
pubmed: 19464786
Toxicol Lett. 2012 May 5;210(3):332-7
pubmed: 22343039
Mol Aspects Med. 2006 Aug;27(4):299-402
pubmed: 16914190
PLoS One. 2014 Oct 22;9(10):e110509
pubmed: 25337790
J Steroid Biochem Mol Biol. 2000 Nov 15;74(4):223-34
pubmed: 11162928
Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):14930-5
pubmed: 22927406
Toxicol Lett. 2002 Sep 5;135(1-2):95-101
pubmed: 12243868
Front Pharmacol. 2019 Jan 08;9:1428
pubmed: 30670963
Environ Pollut. 2011 Jan;159(1):212-218
pubmed: 20875696
Genomics. 1997 Nov 1;45(3):607-17
pubmed: 9367686
J Mol Endocrinol. 2019 Nov;63(4):273-283
pubmed: 31546233
Reprod Toxicol. 2017 Mar;68:130-144
pubmed: 27496714
Int J Obes (Lond). 2013 Jul;37(7):999-1005
pubmed: 23090578
Toxicology. 2017 Jul 15;387:10-16
pubmed: 28645579
J Steroid Biochem Mol Biol. 2008 May;110(1-2):95-103
pubmed: 18359623
Clin Cancer Res. 2007 Aug 15;13(16):4672-6
pubmed: 17699844
Diabetologia. 2013 Sep;56(9):2059-67
pubmed: 23748860
Obesity (Silver Spring). 2015 Feb;23(2):335-44
pubmed: 25451536
PLoS One. 2016 Mar 04;11(3):e0150762
pubmed: 26942597
PLoS One. 2014 Jun 30;9(6):e101252
pubmed: 24978476
Toxicol Lett. 2014 Aug 4;228(3):192-9
pubmed: 24793715
J Steroid Biochem Mol Biol. 2006 Dec;102(1-5):175-9
pubmed: 17088055
Toxicol In Vitro. 2017 Oct;44:287-302
pubmed: 28751236
Biol Reprod. 1997 Dec;57(6):1338-45
pubmed: 9408238
Nutrients. 2020 Feb 19;12(2):
pubmed: 32092919
FASEB J. 2014 Jul;28(7):3124-33
pubmed: 24744145
Am J Transl Res. 2020 Feb 15;12(2):649-659
pubmed: 32194912
Curr Genomics. 2009 May;10(3):169-83
pubmed: 19881910
Genomics. 1998 Jan 15;47(2):310-3
pubmed: 9479505
Toxicol Lett. 2015 Nov 4;238(3):30-8
pubmed: 26276081
BMJ Open. 2011 Nov 14;1(2):e000311
pubmed: 22102643
Toxics. 2016 Sep 26;4(4):
pubmed: 29051427
Environ Sci Technol. 2011 Nov 1;45(21):9372-9
pubmed: 21939283