Interplay between Cell-Surface Receptors and Extracellular Matrix in Skin.


Journal

Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414

Informations de publication

Date de publication:
11 08 2020
Historique:
received: 30 06 2020
revised: 01 08 2020
accepted: 05 08 2020
entrez: 16 8 2020
pubmed: 17 8 2020
medline: 16 6 2021
Statut: epublish

Résumé

Skin consists of the epidermis and dermis, which are connected by a specialized basement membrane-the epidermal basement membrane. Both the epidermal basement membrane and the underlying interstitial extracellular matrix (ECM) created by dermal fibroblasts contain distinct network-forming macromolecules. These matrices play various roles in order to maintain skin homeostasis and integrity. Within this complex interplay of cells and matrices, cell surface receptors play essential roles not only for inside-out and outside-in signaling, but also for establishing mechanical and biochemical properties of skin. Already minor modulations of this multifactorial cross-talk can lead to severe and systemic diseases. In this review, major epidermal and dermal cell surface receptors will be addressed with respect to their interactions with matrix components as well as their roles in fibrotic, inflammatory or tumorigenic skin diseases.

Identifiants

pubmed: 32796709
pii: biom10081170
doi: 10.3390/biom10081170
pmc: PMC7465455
pii:
doi:

Substances chimiques

Extracellular Matrix Proteins 0
Receptors, Cell Surface 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Deutsche Forschungsgemeinschaft
ID : NY90/5-1 and SFB850 project B11
Pays : International

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Auteurs

Svenja Kleiser (S)

Department of Dermatology, Faculty of Medicine and Medical Center, University of Freiburg, Hauptstraße 7, 79104 Freiburg, Germany.
Faculty of Biology, University of Freiburg, Schänzlestraße 1, 79104 Freiburg, Germany.

Alexander Nyström (A)

Department of Dermatology, Faculty of Medicine and Medical Center, University of Freiburg, Hauptstraße 7, 79104 Freiburg, Germany.

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