Effect of kaempferol on the transgenic Drosophila model of Parkinson's disease.
Animals
Animals, Genetically Modified
Disease Models, Animal
Drosophila
/ genetics
Humans
Kaempferols
/ administration & dosage
Lewy Bodies
/ drug effects
Motor Activity
/ drug effects
Parkinson Disease
/ genetics
Protein Aggregation, Pathological
/ prevention & control
Tyrosine 3-Monooxygenase
/ metabolism
alpha-Synuclein
/ antagonists & inhibitors
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
14 08 2020
14 08 2020
Historique:
received:
29
04
2020
accepted:
27
07
2020
entrez:
16
8
2020
pubmed:
17
8
2020
medline:
29
12
2020
Statut:
epublish
Résumé
The present study was aimed to study the effect of kaempferol, on the transgenic Drosophila model of Parkinson's disease. Kaempferol was added in the diet at final concentration of 10, 20, 30 and 40 µM and the effect was studied on various cognitive and oxidative stress markers. The results of the study showed that kaempferol, delayed the loss of climbing ability as well as the activity of PD flies in a dose dependent manner compared to unexposed PD flies. A dose-dependent reduction in oxidative stress markers was also observed. Histopathological examination of fly brains using anti-tyrosine hydroxylase immunostaining has revealed a significant dose-dependent increase in the expression of tyrosine hydroxylase in PD flies exposed to kaempferol. Molecular docking results revealed that kaempferol binds to human alpha synuclein at specific sites that might results in the inhibition of alpha synuclein aggregation and prevents the formation of Lewy bodies.
Identifiants
pubmed: 32796885
doi: 10.1038/s41598-020-70236-2
pii: 10.1038/s41598-020-70236-2
pmc: PMC7429503
doi:
Substances chimiques
Kaempferols
0
alpha-Synuclein
0
kaempferol
731P2LE49E
Tyrosine 3-Monooxygenase
EC 1.14.16.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
13793Références
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