New chloptosins B and C from an Embleya strain exhibit synergistic activity against methicillin-resistant Staphylococcus aureus when combined with co-producing compound L-156,602.
Journal
The Journal of antibiotics
ISSN: 1881-1469
Titre abrégé: J Antibiot (Tokyo)
Pays: England
ID NLM: 0151115
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
04
06
2020
accepted:
20
07
2020
revised:
13
07
2020
pubmed:
17
8
2020
medline:
18
5
2021
entrez:
16
8
2020
Statut:
ppublish
Résumé
Two new dimeric cyclohexapeptides, chloptosins B and C, were discovered from the culture broth of Embleya sp. MM621-AF10 together with the known compounds chloptosin and L-156,602. The structures of the new chloptosins were determined by spectroscopic studies and advanced Marfey's methods. The stereo structure of the constituent isoleucine was determined by C
Identifiants
pubmed: 32796954
doi: 10.1038/s41429-020-0361-y
pii: 10.1038/s41429-020-0361-y
doi:
Substances chimiques
Anti-Bacterial Agents
0
Peptides, Cyclic
0
Pyridazines
0
chloptosin
0
PD 124966
107231-21-0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
80-85Références
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