Reliability of dopamine transporter PET measurements with [

Dopamine transporter Parkinson’s disease Reliability Test-retest [18F]FE-PE2I

Journal

EJNMMI research
ISSN: 2191-219X
Titre abrégé: EJNMMI Res
Pays: Germany
ID NLM: 101560946

Informations de publication

Date de publication:
14 Aug 2020
Historique:
received: 13 05 2020
accepted: 22 07 2020
entrez: 16 8 2020
pubmed: 17 8 2020
medline: 17 8 2020
Statut: epublish

Résumé

Reliable quantification of dopamine transporter (DAT), a biomarker for Parkinson's disease (PD), is essential for diagnostic purposes as well as for evaluation of potential disease-modifying treatment. Due to degeneration of dopaminergic neurons and thus lower expected radioligand binding to DAT, higher measurement variability in PD patients might be expected than earlier reproducibility results in healthy controls. Therefore, we aimed to examine the test-retest properties of [ Nine patients with PD (Hoehn and Yahr stage < 3) were included (men/women 6/3; mean age 65.2 ± 6.8 years). Each patient underwent two [ [ DAT-PET measurements with [ EudraCT 2017-003327-29.

Sections du résumé

BACKGROUND BACKGROUND
Reliable quantification of dopamine transporter (DAT), a biomarker for Parkinson's disease (PD), is essential for diagnostic purposes as well as for evaluation of potential disease-modifying treatment. Due to degeneration of dopaminergic neurons and thus lower expected radioligand binding to DAT, higher measurement variability in PD patients might be expected than earlier reproducibility results in healthy controls. Therefore, we aimed to examine the test-retest properties of [
METHODS METHODS
Nine patients with PD (Hoehn and Yahr stage < 3) were included (men/women 6/3; mean age 65.2 ± 6.8 years). Each patient underwent two [
RESULTS RESULTS
[
CONCLUSION CONCLUSIONS
DAT-PET measurements with [
TRIAL REGISTRATION BACKGROUND
EudraCT 2017-003327-29.

Identifiants

DOI: 10.1186/s13550-020-00676-4 PMID: 32797307 PMC: PMC7427674
pubmed: 32797307
doi: 10.1186/s13550-020-00676-4
pii: 10.1186/s13550-020-00676-4
pmc: PMC7427674
doi:

Types de publication

Journal Article

Langues

eng

Pagination

95

Subventions

Organisme : Vetenskapsrådet (SE)
ID : 2016-02607
Organisme : Vetenskapsrådet (SE)
ID : 523-2014-3467
Organisme : Åhlén-stiftelsen
ID : mA4/h17
Organisme : Karolinska Institutet
ID : 2016-00186

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Auteurs

Vera S Kerstens (VS)

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, and Stockholm Health Care Services, Region Stockholm, Karolinska University Hospital, Stockholm, Sweden. vera.kerstens@ki.se.
ORCID: 0000-0002-5770-8419

Patrik Fazio (P)

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, and Stockholm Health Care Services, Region Stockholm, Karolinska University Hospital, Stockholm, Sweden.

Mathias Sundgren (M)

Department of Clinical Neuroscience, Division of Neuro, Karolinska Institutet, Stockholm, Sweden.
Neurology Department, Karolinska University Hospital, Stockholm, Sweden.

Granville J Matheson (GJ)

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, and Stockholm Health Care Services, Region Stockholm, Karolinska University Hospital, Stockholm, Sweden.

Erika Franzén (E)

Department of Neurobiology, Care Sciences and Society, Division of Physiotherapy, Karolinska Institutet, Stockholm, Sweden.
Function Area Occupational Therapy & Physiotherapy, Allied Health Professionals Function, Karolinska University Hospital, Stockholm, Sweden.

Christer Halldin (C)

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, and Stockholm Health Care Services, Region Stockholm, Karolinska University Hospital, Stockholm, Sweden.

Simon Cervenka (S)

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, and Stockholm Health Care Services, Region Stockholm, Karolinska University Hospital, Stockholm, Sweden.

Per Svenningsson (P)

Department of Clinical Neuroscience, Division of Neuro, Karolinska Institutet, Stockholm, Sweden.
Neurology Department, Karolinska University Hospital, Stockholm, Sweden.

Andrea Varrone (A)

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, and Stockholm Health Care Services, Region Stockholm, Karolinska University Hospital, Stockholm, Sweden.

Classifications MeSH