Pharmacokinetics of bisphenol A in humans following dermal administration.

Administration, Cutaneous Administration, Oral Benzhydryl Compounds Female Half-Life Humans Male Phenols
Absorption Bioavailability Distribution Endocrine disruptor Excretion Metabolism

Journal

Environment international
ISSN: 1873-6750
Titre abrégé: Environ Int
Pays: Netherlands
ID NLM: 7807270

Informations de publication

Date de publication:
11 2020
Historique:
received: 06 05 2020
revised: 29 07 2020
accepted: 31 07 2020
pubmed: 18 8 2020
medline: 12 1 2021
entrez: 18 8 2020
Statut: ppublish

Résumé

Human exposures to bisphenol A (BPA) are widespread. The current study addresses uncertainties regarding human pharmacokinetics of BPA following dermal exposure. To examine the absorption, distribution, metabolism and excretion of BPA in humans following dermal administration. We dermally administered deuterated BPA (d6-BPA) to 10 subjects (6 men and 4 women) at a dose of 100 µg/kg over a 12-hour period and conducted blood and urine analysis from the beginning of dosing through a three- or six-day period. We present time-course serum and urine concentrations of total and unconjugated ("free") d6-BPA and used this information to calculate terminal half-life and area under the curve. Detectable serum levels of total d6-BPA were observed at 1.4 h after the start of dosing, and a maximum serum concentration (C

Sections du résumé

BACKGROUND
Human exposures to bisphenol A (BPA) are widespread. The current study addresses uncertainties regarding human pharmacokinetics of BPA following dermal exposure.
OBJECTIVE
To examine the absorption, distribution, metabolism and excretion of BPA in humans following dermal administration.
METHODS
We dermally administered deuterated BPA (d6-BPA) to 10 subjects (6 men and 4 women) at a dose of 100 µg/kg over a 12-hour period and conducted blood and urine analysis from the beginning of dosing through a three- or six-day period. We present time-course serum and urine concentrations of total and unconjugated ("free") d6-BPA and used this information to calculate terminal half-life and area under the curve.
RESULTS AND CONCLUSIONS
Detectable serum levels of total d6-BPA were observed at 1.4 h after the start of dosing, and a maximum serum concentration (C

Identifiants

DOI: 10.1016/j.envint.2020.106031 PMID: 32798798 PMC: PMC9210257
pubmed: 32798798
pii: S0160-4120(20)31986-3
doi: 10.1016/j.envint.2020.106031
pmc: PMC9210257
mid: NIHMS1815452
pii:
doi:

Substances chimiques

Benzhydryl Compounds 0
Phenols 0
bisphenol A MLT3645I99

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

106031

Subventions

Organisme : Intramural EPA
ID : EPA999999
Pays : United States

Informations de copyright

Copyright © 2020. Published by Elsevier Ltd.

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Auteurs

Alan F Sasso (AF)

U.S. Environmental Protection Agency (US EPA), Office of Research and Development, Center for Public Health and Environmental Assessment (CPHEA), Chemical Pollutant Assessment Division (CPAD), 1200 Pennsylvania Avenue, NW (8623R), Washington, DC 20460, USA. Electronic address: Sasso.Alan@epa.gov.

Ralph Pirow (R)

German Federal Institute for Risk Assessment (BfR), Department of Chemical and Product Safety, Max-Dohrn-Strasse 8-10, 10589 Berlin, Germany. Electronic address: Ralph.Pirow@bfr.bund.de.

Syam S Andra (SS)

Exposure Biology, Senator Frank R. Lautenberg Environmental Health Sciences Laboratory, Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: syam.andra@mssm.edu.

Rebecca Church (R)

Clinical Research Unit, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), P.O. Box 12233, Mail Drop CU-01, Research Triangle Park, NC 27709, USA. Electronic address: rebecca.church@nih.gov.

Rebecca M Nachman (RM)

U.S. Environmental Protection Agency (US EPA), Office of Research and Development, Center for Public Health and Environmental Assessment (CPHEA), Chemical Pollutant Assessment Division (CPAD), 1200 Pennsylvania Avenue, NW (8623R), Washington, DC 20460, USA. Electronic address: nachman.rebecca@epa.gov.

Susanne Linke (S)

German Federal Institute for Risk Assessment (BfR), Department of Chemical and Product Safety, Max-Dohrn-Strasse 8-10, 10589 Berlin, Germany. Electronic address: Susanne.Linke@bfr.bund.de.

Dustin F Kapraun (DF)

U.S. Environmental Protection Agency (US EPA), Office of Research and Development, Center for Public Health and Environmental Assessment (CPHEA), Chemical Pollutant Assessment Division (CPAD), 1200 Pennsylvania Avenue, NW (8623R), Washington, DC 20460, USA. Electronic address: Kapraun.Dustin@epa.gov.

Shepherd H Schurman (SH)

Clinical Research Unit, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), P.O. Box 12233, Mail Drop CU-01, Research Triangle Park, NC 27709, USA. Electronic address: schurmansh@niehs.nih.gov.

Manish Arora (M)

Exposure Biology, Senator Frank R. Lautenberg Environmental Health Sciences Laboratory, Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: manish.arora@mssm.edu.

Kristina A Thayer (KA)

U.S. Environmental Protection Agency (US EPA), Office of Research and Development, Center for Public Health and Environmental Assessment (CPHEA), Chemical Pollutant Assessment Division (CPAD), 1200 Pennsylvania Avenue, NW (8623R), Washington, DC 20460, USA. Electronic address: thayer.kris@epa.gov.

John R Bucher (JR)

Division of the National Toxicology Program (NTP), National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), P.O. Box 12233, Mail Drop K2-02, Research Triangle Park, NC 27709, USA. Electronic address: bucher@niehs.nih.gov.

Linda S Birnbaum (LS)

Division of the National Toxicology Program (NTP), National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), P.O. Box 12233, Mail Drop B2-01, Research Triangle Park, NC 27709, USA. Electronic address: birnbaumls@niehs.nih.gov.

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Classifications MeSH

questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Administration par voie topique › Administration par voie cutanée › Pharmacokinetics of bisphenol A in humans...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Administration par voie orale › Pharmacokinetics of bisphenol A in humans...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Composés benzhydryliques › Pharmacokinetics of bisphenol A in humans...
questionsmedicales.fr › Phénomènes physiques › Temps › Période › Pharmacokinetics of bisphenol A in humans...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Pharmacokinetics of bisphenol A in humans...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Pharmacokinetics of bisphenol A in humans...