The Relationship between Oxidative Stress, Intermittent Hypoxemia, and Hospital Duration in Moderate Preterm Infants.
Biomarkers
Oxidative stress
Preterm infants
Journal
Neonatology
ISSN: 1661-7819
Titre abrégé: Neonatology
Pays: Switzerland
ID NLM: 101286577
Informations de publication
Date de publication:
2020
2020
Historique:
received:
25
02
2020
accepted:
27
05
2020
pubmed:
18
8
2020
medline:
26
8
2021
entrez:
18
8
2020
Statut:
ppublish
Résumé
Lipid peroxidation products are present following oxidation of polyunsaturated fatty acids in the eye, brain, and various cell membranes. Elevated levels of lipid peroxidation products and increased intermittent hypoxemia (IH) events have been associated with adverse outcomes in extremely preterm infants. The moderate preterm newborn has a still-developing oxidant defense system and immature respiratory control, but little is known about lipid peroxidation levels and IH in this larger and more common preterm population. To determine the association between oxidative stress and IH in moderate preterm infants. Oxygen saturation was continuously monitored in 51 moderate preterm infants (i.e., 31 + 0/7 to 33 + 6/7 weeks' gestation). Urine samples were collected at the end of the first and second weeks of life. Samples were analyzed for total lipid peroxidation products (neurofurans, isofurans, neuroprostanes, isoprostanes, and di-homo-isofurans). At week 1, there was a correlation between increased IH frequency and neurofurans (p < 0.04) and di-homo-isofurans (p < 0.003). At week 2, there was no correlation between IH and lipid peroxidation markers. Ele-vations in neurofurans, isofurans, neuroprostanes, and di-homo-isofurans in the first and/or second week of life were associated with a longer stay in hospital. Elevations in lipid peroxidation biomarkers in moderate preterm infants during their first weeks of life are associated with a higher frequency of IH and prolonged hospitalization.
Identifiants
pubmed: 32799210
pii: 000509038
doi: 10.1159/000509038
pmc: PMC7854776
mid: NIHMS1603496
doi:
Substances chimiques
Isoprostanes
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
577-583Subventions
Organisme : NICHD NIH HHS
ID : T32 HD060537
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL133643
Pays : United States
Informations de copyright
© 2020 S. Karger AG, Basel.
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