Paramagnetic Rim Lesions are Specific to Multiple Sclerosis: An International Multicenter 3T MRI Study.
Journal
Annals of neurology
ISSN: 1531-8249
Titre abrégé: Ann Neurol
Pays: United States
ID NLM: 7707449
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
28
05
2020
revised:
12
08
2020
accepted:
13
08
2020
pubmed:
18
8
2020
medline:
15
12
2020
entrez:
18
8
2020
Statut:
ppublish
Résumé
In multiple sclerosis (MS), a subset of chronic active white matter lesions are identifiable on magnetic resonance imaging by their paramagnetic rims, and increasing evidence supports their association with severity of clinical disease. We studied their potential role in differential diagnosis, screening an international multicenter clinical research-based sample of 438 individuals affected by different neurological conditions (MS, other inflammatory, infectious, and non-inflammatory conditions). Paramagnetic rim lesions, rare in other neurological conditions (52% of MS vs 7% of non-MS cases), yielded high specificity (93%) in differentiating MS from non-MS. Future prospective multicenter studies should validate their role as a diagnostic biomarker. ANN NEUROL 2020;88:1034-1042.
Identifiants
pubmed: 32799417
doi: 10.1002/ana.25877
pmc: PMC9943711
mid: NIHMS1873502
doi:
Types de publication
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1034-1042Subventions
Organisme : NINDS NIH HHS
ID : R01 NS082347
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA NS003119
Pays : United States
Informations de copyright
© 2020 American Neurological Association.
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